Relevance. Dental care for children with autism spectrum disorders (ASD) requires modification of the conventional treatment setting, which includes many sensory stimuli that influence the behaviour of these children. However, it is not possible to eliminate all dental treatment stimuli from clinical practice. The development of a new method for digital priming of neurodiverse patients was facilitated by the need to mitigate unavoidable dental treatment stimuli to achieve sensory deprivation, expressed as reduced anxiety and improved cooperation.

The study aimed to investigate the level of cooperation and anxiety in children with ASD before and during dental treatment using a developed mobile application.

Material and Methods. Forty-three children aged 7 and 12 years old with con-firmed ASD of varying severity participated in the study. The cooperation and anxiety level in children with ASD were assessed according to the Larry L. Venham clinical anxiety rating scale before and during treatment using the mobile application.

Results. During dental treatment, the children with mild/moderate autism showed a statistically significant (p < 0.05) decrease in their anxiety level and improvement of the cooperativeness profile, which indicates a positive effect of the developed mobile application on the level of anxiety and cooperation.

Conclusion. Further research is necessary to evaluate similar information and communication technology types as a part of significant approaches to sensory deprivation, behaviour improvement, and dental treatment outcomes in vulnerable children.

Relevance. The eruption of deciduous teeth is a distinct physiological process marked by local and systemic manifestations, along with alterations in oral microbiota in children.

Research objective. A comparative clinical study evaluating the efficacy of different medications in managing localized symptoms during challenging deciduous teeth eruption, alongside an assessment of a homeopathic medicine's influence on oral microbiota in children (in vitro).

Material and methods. The study encompassed 120 infants ranging from 5 months to 2 years old, randomized into three groups (40 individuals per group), all experiencing challenging deciduous teeth eruption. The research groups were assigned the following interventions: a homeopathic medicine, a dental gel containing an antiseptic and analgesic properties, and a dental gel infused with plant extracts. Clinical assessments of the children were performed using the E.M. Kuzmina index (2000), while concurrent evaluations of the oral microbiota were also conducted.

Results. After the course of the medicinal homeopathic preparation, the condition of the gums, as per the E.M. Kuzmina index, indicated good oral hygiene, in contrast to medicinal preparations containing synthetic and plant-based antiseptics and anesthetics, which resulted in a satisfactory level of oral hygiene. Microbiological research indicated that the utilization of the investigated samples of the homeopathic medicine facilitated the creation of conditions fostering indirect competition of the stabilizing oral micro versus the pathogenic group of microorganisms.

Conclusion. The clinical effectiveness of the homeopathic medicine for challenging deciduous teeth eruption was notably higher. A more substantial positive trend was observed in relation to the oral microbiota in children following the twice-daily application of the homeopathic medicine solution.

Relevance. Malocclusions in children present a pressing concern in the field of dentistry. Timely diagnostics and treatment of these conditions are crucial for children aged 6 to 18, residing in foster homes, where incidence tend to be higher compared to children raised in family settings. This heightened incidence is often attributed to the lack of timely examinations by pediatric dentist or orthodontists. Such examinations could have potentially prevented the development of malocclusions or facilitated the administration of appropriate orthodontic treatments.

Materials and methods. The study included 200 children aged 6 to 18, categorized into two groups: 100 children residing in foster homes or orphanages and 100 living with families (control group). Various malocclusions were identified using the Dental Aesthetic Index (DAI) dental aesthetic index and Angle's classification.

Results. Malocclusions were identified in 89.3% of the children from foster home, compared to 66.6% of children from family households. The most prevalent types of malocclusions observed were crowding of front teeth and incisor cross-bite. The DAI dental aesthetic index was higher in children from foster home (DAI = 30.4) than in those from family (DAI = 27.8). Additionally, it was observed that none of the children from foster homes had undergone orthodontic treatment, in contrast to the children in the control group.

Conclusion. The study underscores the significance of diagnosing and treating malocclusions in children, with particular emphasis on those residing in foster homes. The results highlight the necessity of implementing effective methods to prevent and address malocclusions in such environments, aiming to enhance the dental health of the children.

Relevance. The incidence of malignant growths in the maxillofacial area has consistently increased over the years. Chemotherapy stands out as one of the most effective treatments for cancerous tumors. Chemotherapeutic drugs possess the capability to either inhibit the proliferation of malignant cells or cause damage to them. However, while acting on abnormal cells, cytostatic drugs also impact actively dividing cells in normal tissues, including the mucous membranes in the oral cavity. As a result, various complications are observed in every patient undergoing treatment for malignant neoplasms (MN), particularly chemotherapy (CT). The nature and severity of side effects undergo changes based on the specific drugs and cytostatic treatment regimen employed. Adverse reactions and side effects inherent to each drug category manifest at different points throughout a chemotherapy course and its aftermath. Oral mucosal (OM) complications, such as oral mucositis, may ensue as a consequence of CT side effects.

Materials and methods. In order to assess the effectiveness of screening for OM disorders arising as side effects of chemotherapy, a study involving 37 patients undergoing chemotherapy for an underlying condition was conducted. The screening study comprised two stages: Stage I involved a quality-of-life assessment utilizing questionnaires developed by the authors, while Stage II entailed a clinical examination of the oral mucosa. The obtained data were subjected to statistical analysis methods. Variation statistics were employed to assess the likelihood of data errors.

Results. Comprehensive OM diagnostics in patients undergoing chemotherapy for an underlying oncology condition enable the early identification of oral mucosal diseases and the prevention of complications. It is recommended to conduct a thorough clinical examination and employ toluidine blue staining during each follow-up visit. Any observed clinical or stained tissue changes, the emergence of new erythematous lesions, erosions, or ulcers may serve as indicators of malignant transformation.

Conclusion. It is advisable to incorporate screening diagnostics into each patient's dental visit to proactively prevent the onset of various pathological conditions.

Relevance. Maxillofacial deformities and speech disorders are common types of oral pathology detected in children under seven years. Comprehensive rehabilitation of patients with a combination of these forms of pathology is a difficult task since there is no situational analysis of their prevalence; motivated specialists work in different institutions (education, healthcare) and have different guidelines for the treatment (correction) of existing diseases (disorders), which complicates planning and administering treatment, and predicting results.

Material and methods. To identify the nature of the relationship between various forms of orthodontic and speech disorders in children, we conducted a comprehensive clinical dental examination of 80 children aged 4-6 years in a preschool educational institution, where children with speech disorders receive speech therapy assistance.

Results. Maxillofacial deformities appeared to be in 56.25% of children with some speech sound disorder. Children with identified speech sound disorders combined with dentofacial deformities showed not only skeletal but also soft tissue defects: shifted midline (86.67 ± 0.10%), distal occlusion (42.22 ± 0.30%), deep overbite (46.68%), as well as tongue and upper lip ties in 51.10% and 22.20% of cases, respectively. On examination, 44.45% of patients demonstrated clinical signs of mouth breathing, 32.5% – reverse swallowing, and 53.33% – inefficient chewing.

Conclusion. Analysis of the results of a comprehensive speech pathology assessment and dental examination allowed us to conclude that there is a need to rethink the methodology of diagnosis, prevention and treatment of combined speech and dental disorders due to the high frequency of their comorbidity in preschool children.

Relevance. The progression of caries during pregnancy is significantly influenced by the resistance of dental tissues against demineralization. The degree of resistance in dental enamel is influenced by its genetic determinants, encompassing structural and morphological properties. The kallikrein 4 (KLK4) gene plays a pivotal role as a primary enzyme in dental enamel formation. Consequently, evaluating the effectiveness of various preventive measures on dental enamel necessitates consideration of KLK4 gene mutations.

Material and methods. An examination was conducted on a cohort of 322 pregnant women. Key indices assessed included OHI-S, DMF, DMFs, ∆DMF, and ∆DMFs. Oral fluid analysis encompassed parameters such as Ca, P, Ca/P-molar ratio, рН, Ca²⁺, pK⁺, pNa⁺. The sediment of oral fluid was examined for ∆рН and ∆Ca. DNA sample was isolated from venous blood obtained from the participants.

Results. The G/G polymorphism of the KLK4 gene at positions G2664153A and G2142А did not exhibit a statistically significant association with an increase in the ∆DMFs index during caries prevention, a finding consistent across both discussed tools for exogenous caries prevention in this study. In case of heterozygous KLK4 G/A polymorphism with the dominant G allele, the application of Enamel Sealing Liquid showed a tendency towards higher ∆DMF and ∆DMFs indices over a 12-month follow-up period. When pregnant patients with heterozygous dominant G allele mutations were treated with the triple-component calcium-fluorine-phosphate-containing gel, there were no observed elevations in these indices. The amplified production of KLK4 A/A polymorphism was associated with a statistically significant rise in ∆DMF and ∆DMFs indices, accompanied by alterations in certain oral fluid parameters. These changes included reduced active calcium levels and Ca/P molar ratio, along with elevated levels of phosphates and electrolytes. Enhanced demineralizing activity was observed in the oral fluid sediment.

Conclusion. The effectiveness of caries prevention tools during pregnancy is contingent upon the genotypic diversity of KLK4 gene polymorphism at the G2664153A and G2142А mutation points.

Relevance. This article addresses the prevalence of periodontal diseases in infants and preschool-aged children, considering factors such as the child's age and family structure within the region of the Republic of Tatarstan. Periodontal diseases, in conjunction with dental caries and dental abnormalities, represent the most frequently observed oral health conditions among children and adolescents.

Materials and methods. The research involved 2429 families and 2556 preschool-aged children representing diverse family structures within Kazan, Arsk, and Pestrechinsky districts in the Republic of Tatarstan. During the survey, five primary family classifications emerged: complete, incomplete, extended, reconstituted, and foster families. The research methodology involved conducting interviews with parents, close relatives, or guardians, coupled with comprehensive examinations of the children, documenting both systemic disease and general health information using specifically tailored charts. Data analysis included determining mean values (M), mean error of the score (m), and Student's t-test criterion (t). Significance among group disparities was established at a probability of error less than 5% (p < 0.05). The gathered data underwent interpretation, considering both family structure and the spectrum of periodontal diseases.

Results. Periodontal diseases were found to affect children from foster and incomplete families most significantly, with prevalence rates exceeding 90% in certain age groups. Children from complete and extended families exhibited lower prevalence rates of periodontal diseases, at 9.8% and 22.2%, respectively. Notably, within all age brackets, the highest occurrence of periodontal diseases was observed among children aged 4.6-6 years, constituting 57.0% of cases. Infants under one year old displayed the lowest susceptibility, with only 16.3% affected. Upon analyzing disease prevalence among children in the Republic of Tatarstan, a significant disparity emerged: children residing in rural areas demonstrated a higher susceptibility to periodontal diseases in comparison to their urban counterparts.

Conclusion. The findings reveal a clear correlation between a child's family structure and the occurrence of periodontal diseases. Establishing the family structure and implementing tailored preventive measures specific to periodontal diseases, while considering both the child's family structure and age, plays a significant role in averting the onset and progression of this condition.

Relevance. A pulpectomy is a procedure predominantly performed for pulpitis treatment in single-rooted primary teeth. Data on the pulpectomy in primary molars are limited. Pulpectomy in children with negative behaviour is particularly difficult. The study aimed to determine the survival rate of primary molars after treatment of chronic pulpitis by pulpectomy in children with negative behaviour depending on the behaviour management method.

Material and methods. A prospective clinical study in parallel groups involved 120 children aged 3-6 years who demonstrated negative behaviour (according to the Frankl scale) during a dental examination. Chronic fibrous pulpitis was treated by vital pulpectomy in 180 primary molars. In group 1 (60 children, 90 teeth), children underwent non-pharmacological behaviour management; in group 2, children were treated under conscious sedation (pharmacological correction of behaviour). Follow-ups after 6, 12, 18 and 24 months determined the tooth survival rate after pulpectomy.

Results. The 24-month tooth survival rate after pulpectomy was 76.7% in group 1 (95% CI 67.9-85.4%), 81.1% – in group 2 (95% CI 73.0-89.2%), p > 0.05.

Conclusion. More than 75% of primary molars survived for 24 months after vital pulpectomy in children with negative behaviour. The results of pulpectomy with pharmacological behaviour correction were better than after non-pharmacological behaviour management; however, the detected differences were not statistically significant.

Relevance. Properly selected personal oral hygiene products play a crucial role in minimizing the risk of hard tissue and periodontal diseases while also preventing their development. Consequently, there is a need for research to assess the effectiveness of various oral hygiene products and their combinations.

The objective of our study was to compare the clinical efficacy of a mouthwash and an irrigant in patients with fixed or removable orthodontic appliances.

Materials and methods. The study comprised 60 patients aged 20 to 29, all without medical conditions. Participants were evenly divided into two groups, each consisting of 30 individuals. The first group utilized Asepta Fresh mouthwash (Werteks Ltd, Russian Federation), while the second group used both a mouthwash and irrigant from the this brand.

Results. The study observed quantitative changes in the following indices: Lange’s API, Silness – Loe, Green – Vermillion (OHI-S), and Ulitovsky – Orekhova’s HI ORTHO (Hygiene Index ORTHOdontic). Throughout the study, based on the alterations in these indices, both groups showed an improvement in oral hygiene. However, it is noteworthy that the positive trends were more pronounced in the second group.

Conclusion. The use of liquid products such as Asepta Fresh (Werteks Ltd, Russian Federation) in personal oral hygiene practices proves to be a sufficiently effective method for cleaning approximal tooth surfaces. This effectiveness is substantiated by the positive changes observed in oral hygiene measured by the aforementioned indices. Hence, it may be recommended as an auxiliary method for controlling oral hygiene in orthodontics with fixed appliances.

Relevance. Postural disorders and their connection to dentofacial abnormalities represent a prominent subject in modern medicine, establishing a new diagnostic standard within the emerging fields of orthodontic and osteopathic diagnostic techniques.

Objective. Establish a correlation between asymmetric narrowing of maxilla and postural disorders in children and teens aged 6 to 15 years. Substantiate the necessity for a combined approach involving both orthodontic and osteopathic diagnostics in this age group, aiming to develop a comprehensive treatment algorithm.

Materials and methods. Orthodontists and an osteopathic physician conducted diagnostic procedures for 320 subjects. Verification methods included standardized questionnaires for orthodontics and osteopathy, digital photography, radiological analysis using cone beam computer tomography (CBCT) of the head, electromyography (EMG), and computer-aided optical postural topography with the DIERS formetric 4D motion system.

Results. Among the 320 subjects examined, the study revealed that 65% presented with an asymmetric narrowing of maxilla. Digital photography illustrated deviations from the norm in the total width of the maxilla for all subjects, a critical factor influencing proper tongue posture, swallowing, and breathing patterns. Facial asymmetry and temporomandibular disorders (TMD) were prevalent among the majority of patients, with a reported mandibular deviation observed in 100% of cases. Based on CBCT data, the transverse dimension of the asymmetrically narrow maxilla, relative to the mid-sagittal axis, was found to be reduced, along with a concomitant displacement of the greater wings of the sphenoid bone. The measured electric activity of masticatory and temporal muscles supported the diagnosis of asymmetric muscular dysfunction. Additionally, irregularities in the sphenobasilar synchondrosis (SBS) were identified. Moreover, patients with asymmetric maxillary narrowing exhibited static and dynamic imbalance in the body, along with disorders of body posture and foot profile. These observations were made through visual assessment, manual testing, and the DIERS formetric 4D motion optical posture topography system.

Conclusion. Asymmetric maxillary narrowing strongly correlated with posture disorders, static and dynamic imbalances in the body, and dysfunctions in primary activities such as chewing, swallowing, breathing, and gait patterns. To achieve a predictable outcome without complications, it is recommended to pursue both orthodontic and osteopathic treatments for cases involving an asymmetric narrowing of maxilla.

Relevance. Cancer stands as a prominent cause of untimely mortality in young and middle-aged individuals (aged 20-64 years). The inquiry into the extent of influence exerted by external risk factors on the emergence of oral mucosal oncopathology remains pertinent. Equally crucial is understanding the intricate interplay among different groups of factors and their effects.

Research objective. To determine the extent of influence exerted by various endogenous and exogenous risk factors on the development of malignant oral mucosal lesions, based on contemporary literature data, and to assess their interrelationships.

Materials and methods. The research material was the analysis of literary data from bibliographic sources – Elsevier, PubMed, Elibrary, Google Academy, Medline, Cyberleninka. The study included literature sources in Russian and English. The second part of the review combines studies devoted to the study of the influence of exogenous controlled factors on the risk of developing malignant neoplasms of the oral mucosa.

Results. Through contemporary literature analysis, the potential and scale of influence attributed to controllable exogenous risk factors in the development of malignant oral mucosal lesions have been established. Notably, significant impact has been associated with smoking and alcohol consumption. Additionally, adverse socio-economic conditions, environmental factors, and dietary habits have been identified as contributors to an elevated cancer risk. Throughout this investigation, it became evident that literature sources frequently highlight the influence of individual factors without adequately considering potential synergies, antagonistic effects, or interactions with endogenous factors. Moreover, certain factors pivotal to the carcinogenesis of oral cavity tumors remain inadequately researched.

Conclusion. To facilitate efficient primary and secondary prevention measures, it is imperative to advance and refine a multidisciplinary research methodology. This approach should aim to comprehensively identify the collective impact of diverse groups of risk factors on the progression of malignant oral mucosal lesions.

Relevance. The calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a locally aggressive neoplasm characterized by strands and medullary formations of flat and clear cells, often accompanied by spherical calcifications and amyloid-stained hyaline deposits. The Pindborg tumor is rare, representing less than 1% of odontogenic tumors, and typically manifests in individuals aged 20 to 60 years. However, there is a growing incidence of neoplasms of diverse origins in childhood. This article presents a clinical case detailing the comprehensive multi-stage treatment of a pediatric patient with a Pindborg tumor, facilitating complete rehabilitation before reaching adulthood.

Clinical case description. This article presents a clinical case detailing the comprehensive management of a patient with a Pindborg tumor. The individual initially sought treatment at the Department of Pediatric Maxillofacial Surgery of A.I. Evdokimov Moscow State Medical and Dental University in 2020, undergoing complete combined treatment until November 2023. Full rehabilitation was successfully achieved by the time of adulthood through a series of four consecutive surgeries, including dental implantation, followed by prosthetics utilizing a non-removable orthopedic structure in the final stage.

Conclusion. Initiating comprehensive rehabilitation at an early stage, including dental implantation before reaching adulthood, facilitates complete social adaptation in society and contributes to the patient's harmonious development.

Relevance. The prevalence of dental injuries in children reaches 52.3%, based on age. Currently, the number of traumas of anterior maxillary teeth tends to increase. The search and application of the most optimal treatment options for dental injuries in an aesthetic area in children remains relevant.

Description of the clinical case. The article presents the treatment results of an 8-year-old boy diagnosed with S02.52 according to ICD-10: fracture of the crown of tooth 2.1 within the enamel, dentin layers with pulp involvement. Vital amputation of the crown pulp with a direct pulp capping with "Rutdent", an MTA-based product, was chosen as the tactic of dental care. A tooth fragment was attached with a composite material (using an adhesive protocol) for aesthetic rehabilitation. The function and aesthetics of the tooth were restored. The result was stable six months after the treatment.

Conclusion. The popularization of various sports events can lead to an increase in the incidence of dental traumas to anterior teeth in children. A pediatric dentist should be able to apply modern methods of diagnosing acute dental trauma to make the correct diagnosis and choose the optimal treatment method. The opportunities of modern pediatric dentistry allow the restoration of all dental functions lost during trauma: anatomical, aesthetic and physiological.