Salivary facies morphology in children with hematologic malignancies
https://doi.org/10.33925/1683-3031-2025-930
Abstract
Relevance. Leukemias and their treatment produce broad systemic effects in children and frequently involve the oral cavity, leading to qualitative and quantitative changes in saliva. Analysis of salivary facies using the wedge-shaped dehydration method is a useful morphological approach for characterizing disease-related alterations, including those associated with hematologic malignancies.
Objective. To compare the morphology of salivary facies in healthy children and in children with hematologic malignancies.
Materials and methods. The study was conducted at the Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and at the Pediatric Dentistry Department Transplantation of the Pavlov First Saint Petersburg State Medical University. Facies of the supernatant fraction of saliva were prepared by wedge-shaped dehydration, affixed to Litos System glass plates, and assessed according to the Shatokhina–Shabalin clinical crystallography method (1998). Comparison endpoints included quantitative parameters of the marginal zone, facies type, degree of amorphization, and the presence of pathologic markers.
Results. Children with hematologic malignancies showed a larger marginal-zone area (twofold, p < 0.01) and a higher marginal-zone/total facies area ratio (1.5-fold, p < 0.01) than healthy controls. Marginal-zone pigmentation was twice as common, and discontinuous spiral cracks were four times more frequent. Back-arcaded cracks, continuous spiral cracks, and partial or complete amorphization were observed only in the hematologic malignancies group (p≤0.05).
Conclusion. The morphology of salivary facies in children with hematologic malignancies differs substantially from that of healthy peers, indicating impaired salivary homeostatic function.
About the Authors
N. A. Koren
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Nadezhda A. Koren, DMD, Assistant Professor, Department of the Pediatric Dentistry and Orthodontics
6 Lev Tolstoy Str., Saint Petersburg, 197022
T. B. Tkachenko
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Tatyana B. Tkachenko, DMD, PhD, DSc, Professor, Dean of the Dental School, Head of the Department of Pediatric Dentistry and Orthodontics
Saint Petersburg
O. V. Guseva
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Oksana V. Guseva, fourth-year student, Dental School
Saint Petersburg
N. Yu. Sheveleva
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Nina Yu. Sheveleva, DMD, PhD, Associate Professor, Department of the Pediatric Dentistry and Orthodontics
Saint Petersburg
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Review
For citations:
Koren N.A., Tkachenko T.B., Guseva O.V., Sheveleva N.Yu. Salivary facies morphology in children with hematologic malignancies. Pediatric dentistry and dental prophylaxis. 2025;25(2). (In Russ.) https://doi.org/10.33925/1683-3031-2025-930
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