Association of IL-lct gene polymorphism with susceptibility to type gingival recession in children

Abstract

Relevance. Currently, the problem of studying the molecular genetic mechanisms of predisposition to the occurrence of gum recession, formation, prevalence and risk factors remains highly relevant. Aim. To determine the association of the rs1800587 C/T polymorphism of the interleukin 1-a (IL-la) gene with a predisposition to gum recession in children. Materials and methods. A total of 84 patients (41 girls, 43 boys) with varying degrees of a gingaval recession aged 6 to 12 years (mean age 8.12 ± 1.06 years) and 159 healthy patients (comparison group) have been studied. The definition of the rs1800587 C/T polymorphism of the IL-la gene is carried out by the method of polymerase chain reaction. Estimate the subordinate distribution of the Hardy-Weinberg equilibrium sampling genotypes, the X² test, and the estimated odds ratio (OR) with a 95% confidence interval (Cl). Results. In the present study, we compared the frequency distribution of alleles and genotypes in the polymorphic locus of the IL-la C (-889) T (rs!800587) gene between patients with gingival recession and a control group residing in Kazan, the Republic of Tatarstan. In the studied samples of children with recession, the gingivals and the comparison group of the frequency distribution of alleles and genotypes of polymorphic markers had no deviations from the Hardy-Weinberg equilibrium. When analyzing the genetic model, we found that the frequency of occurrence of the minor T allele practically did not differ between sick and healthy patients (28.6% vs. 31%; X² = 0.34, p = 0.56). Conclusions. The rs!800587 C/T polymorphism of the IL-la gene is not associated with a predisposition to the development of gingival recession in children. Turther research is needed to identify the role of IL-la gene polymorphisms in the development of this pathology.