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The opportunities for normalizing oral microbiota in infants with challenging deciduous teeth eruption

https://doi.org/10.33925/1683-3031-2023-697

Abstract

Relevance. The eruption of deciduous teeth is a distinct physiological process marked by local and systemic manifestations, along with alterations in oral microbiota in children.

Research objective. A comparative clinical study evaluating the efficacy of different medications in managing localized symptoms during challenging deciduous teeth eruption, alongside an assessment of a homeopathic medicine's influence on oral microbiota in children (in vitro).

Material and methods. The study encompassed 120 infants ranging from 5 months to 2 years old, randomized into three groups (40 individuals per group), all experiencing challenging deciduous teeth eruption. The research groups were assigned the following interventions: a homeopathic medicine, a dental gel containing an antiseptic and analgesic properties, and a dental gel infused with plant extracts. Clinical assessments of the children were performed using the E.M. Kuzmina index (2000), while concurrent evaluations of the oral microbiota were also conducted.

Results. After the course of the medicinal homeopathic preparation, the condition of the gums, as per the E.M. Kuzmina index, indicated good oral hygiene, in contrast to medicinal preparations containing synthetic and plant-based antiseptics and anesthetics, which resulted in a satisfactory level of oral hygiene. Microbiological research indicated that the utilization of the investigated samples of the homeopathic medicine facilitated the creation of conditions fostering indirect competition of the stabilizing oral micro versus the pathogenic group of microorganisms.

Conclusion. The clinical effectiveness of the homeopathic medicine for challenging deciduous teeth eruption was notably higher. A more substantial positive trend was observed in relation to the oral microbiota in children following the twice-daily application of the homeopathic medicine solution.

About the Authors

L. P. Kiselnikova
A. I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Larisa P. Kiselnikova, DMD, PhD, DSc, Professor, Head of the Department of Pediatric Dentistry

Moscow



V. N. Tsarev
A. I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Victor N. Tsarev, DMD, PhD, DSc, Professor, Director of the Research Institute of Medicine and Dentistry, Head of the Department Microbiology, Virology, Immunology

Moscow



F. M. Balaphendieva
A. I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Fatima M. Balaphendieva, DMD, Assistant Professor, Department of Pediatric Dentistry

Moscow



M. S. Podporin
A. I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Mikhail S. Podporin, DMD, PhD, junior researcher, Laboratory of the Molecular and Biological Research, Research Institute of Medicine and Dentistry

Moscow



P. K. Borodina
A. I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation

Polina K. Borodina, 5th year student, N.A. Semashko Higher School of Clinical Medicine

Moscow



References

1. Zakharova IN, Kholodova IN, Dmitrieva YA, Morozova NV, Mozzhukhina MV, Kholodov DI. Can the physiological process of teething in babies be abnormal? Meditsinskiy sovet = Medical Council. 2016;1(1):30-35 (In Russ.). doi: 10.21518/2079-701X-2016-1-30-35

2. Kazyukova TV, Radzig EYu, Pankratov IV, Aleev AS. Comparison of clinical efficacy and safety of the two drugs in the therapy of symptoms of eruption of infant teeth (“dantinorm baby®” vs “calgel®”). Pediatria n.a. G.N. Speransky. 2018;97(1):122-130. Available from: https://pediatriajournal.ru/archive?show=362§ion=5150

3. Macknin ML, Piedmonte M, Jacobs J, Skibinski C. Symptoms associated with infant teething: a prospective study. Pediatrics. 2000;105(4 Pt 1):747-752. doi: 10.1542/peds.105.4.747

4. Tighe M, Roe MF. Does a teething child need serious illness excluding? Arch Dis Child. 2007;92(3):266-268. doi: 10.1136/adc.2006.110114

5. American Academy of Pediatrics. Teething: 4 to 7 Months. Available from: http://www.healthychildren.org/English/ages-stages/baby/teething-tooth-care/pages/Teething-4-to-7-Months.aspx

6. Drobotko L.N., Zueva T.E. Eruption of temporary teeth in children. Meditsinskiy sovet = Medical Council. 2022;(12):21-27 (In Russ.). doi: 10.21518/2079-701X-2022-16-12-21-27.

7. Kiselnikova LP, Kirillova EV, Tsarev VN, Artemova VO. Microbiological monitoring of a condition of a dental biofilm after application of chlorxedine and xylitol in complex treatment of Early Childhood Caries. Pediatric dentistry and dental prophylaxis. 2009;8(2):74-82 (In Russ.). Available from: https://www.elibrary.ru/item.asp?id=12807997&ysclid=lqcopu1hlw651887443

8. Semenchikova A, Ikonnikova NV. Quantitative and qualitative characteristics of oral microflora as a factor in the formation of the body’s immune defense / Information and Computing Center of the Ministry of Finance, 2018. – Part 1. – P. 332-333. ISBN:978-985-720518-9; 978-985-7205-19-6 (p. 1).

9. Zaura E, Nicu EA, Krom BP, Keijser BJ. Acquiring and maintaining a normal oral microbiome: current perspective. Front Cell Infect Microbiol. 2014;4:85. doi: 10.3389/fcimb.2014.00085

10. Carlsson J, Grahnén H, Jonsson G, Wikner S. Establishment of Streptococcus sanguis in the mouths of infants. Arch Oral Biol. 1970;15(12):1143-1148. doi: 10.1016/0003-9969(70)90005-1

11. Cole MF, Evans M, Fitzsimmons S, et al. Pioneer oral streptococci produce immunoglobulin A1 protease. Infect Immun. 1994;62(6):2165-2168. doi: 10.1128/iai.62.6.2165-2168.1994

12. Könönen E, Asikainen S, Saarela M, Karjalainen J, Jousimies-Somer H. The oral gram-negative anaerobic microflora in young children: longitudinal changes from edentulous to dentate mouth. Oral Microbiol Immunol. 1994;9(3):136-141. doi: 10.1111/j.1399-302x.1994.tb00049.x

13. Burduli AG, Balmasova IP, Tsarev VN, Arutyunov SD. Periodontal diseases and their association with unwanted pregnancy outcomes. Obstetrics and Gynecology. 2022;4:26-33. doi: 10.18565/aig.2022.4.26-33


Review

For citations:


Kiselnikova L.P., Tsarev V.N., Balaphendieva F.M., Podporin M.S., Borodina P.K. The opportunities for normalizing oral microbiota in infants with challenging deciduous teeth eruption. Pediatric dentistry and dental prophylaxis. 2023;23(4):320-328. (In Russ.) https://doi.org/10.33925/1683-3031-2023-697

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ISSN 1683-3031 (Print)
ISSN 1726-7218 (Online)