Analysis of dental status in children with type I diabetes mellitus: a literature review

Relevance. Diabetes mellitus is one of the most complex metabolic chronic diseases. Severe forms of type I diabetes mellitus are more common in children and adolescents, and its prevalence is increasing in many countries. Type I diabetes mellitus in children and adolescents remains an essential health issue in many countries despite the achieved scientific and practical results and progress in diabetology. Therefore, its early detection in children is still relevant and is associated with the early diagnosis of endocrinolog ical pathologies.

Materials and methods. The study searched the publications in PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), Medline (www.elibrary.ru, www.ncbi.nlm.nih.gov/pubmed) by the specific keywords.

Results. In children with diabetes mellitus, vascular changes in periodontal tissues appear earlier than in other organs. On oral examination of children with diabetes mellitus, 50% of cases reveal periodontal lesions, and the lesions are often in the areas of the lower molars. If not treated, the following perio-dontitis signs are present in diabetic children: bleeding of the gingival papillae and the bright red colour of the gingival margin. There may be bulging of granulations from pathological gingival pockets. In most patients with type I diabetes mellitus, cytology of the periodontal pockets and gingival sulci demonstrated inflammatory cytologic responses, changes in the stratified squamous epithelium, and mixed bacterial microflora with leukocytes and erythrocytes.

Conclusion. The study of type I diabetes mellitus impact on pathological changes in the oral cavity of children and the development of therapeutic and preventive measures is a relevant issue in pediatric dentistry, which justifies the need to continue research in this area.

1. Dedov II, Shestakova MV, Vikulova OK. Epidemiology of diabetes mellitus in the Russian Federation: clinical and statistical report according to the Federal Register of Diabetes Mellitus. Diabetes mellitus. 2017;20(1):13-41 (In Russ.). doi: http://dx.doi.org/10.14341/DM8664

2. Abidin Z, Zainuren ZA, Noor E, Mohd Nor NS, Mohd Saffian S, Abdul Halim R / Periodontal Health Status of Children and Adolescents with Diabetes Mellitus: A Systematic Review and Meta-Analysis. Australian dental journal. 2021;66(1):15-26. doi: 10.1111/adj.12845

3. Novotna M, Podzimek S, Broukal Z, Lencova E, Duskova J. Periodontal Diseases and Dental Caries in Children with Type 1 Diabetes Mellitus. Mediators of Inflammation. 2015;2015:379626. doi: 10.1155/2015/379626

4. Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol Metab. 2000;11(9):375-378. doi: 10.1016/s1043-2760(00)00305-2

5. Iordanishvili AK, Soldatkina AS, Serikov AA. Dental diseases in persons of military age. Bulletin of the Russian Military Medical Academy. 2015;4:(52):106-108 (In Russ.). Available from: https://www.vmeda.org/wp-content/uploads/2016/ pdf/2_106-108.pdf

6. Iordanishvili AK, Soldatkina AS. Diseases of mouth organs and tissues in young person. The Dental Institute. 2015;3(68):38-40 (In Russ.). Available from: https://instom.spb.ru/catalog/article/10346/?view=pdf

7. Domenyuk DA, Davydov BN, Gilmiyarova FN, Ivchenko LG. Clinical-diagnostic value of activity of matrix metal proteinasees and their tissue inhibitors in assessment of the state of paronont tissue in children with sugar diabetes of the first type. Part II. Pediatric dentistry and dental prophylaxis. 2018;17(1):37-46 (In Russ.). doi: 10.25636/PMP.3.2018.1.9

8. Sonne DP, Hemmingsen B. Comment on American Diabetes Association. Standards of Medical Care in Diabetes-2017. Diabetes Care 2017;40(Suppl. 1):S1-S135. Diabetes Care. 2017;40(7):e92-e93. doi: 10.2337/dc17-0299

9. IDF DIABETES ATLAS 9-th edition 2019 Chapter 3 Global picture. Diabetes incidence and prevalence in children and adolescents. Available from: https://diabetesatlas.org/en.

10. Dedov II, Shestakova MV, Vikulova OK, Zheleznyakova AV, Isakov MA. Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021. Diabetes mellitus. 2021;20(3):204-221 (In Russ.). doi: 10.14341/DM12759

11. Domenyuk DА, Davydov BN, Gilmiyarova FN, Ivchenko LG. Optimization of the diagnosis of diabetes mellitus type I in children the results of cytomorphological studies of buccal epithelium and processes of oxidative stress in the oral cavity. Pediatric dentistry and dental prophylaxis. 2017;16(3):9-18 (In Russ.). Available from: https://www.detstom.ru/jour/article/view/71

12. Jain A, Chawla M, Kumar A, Chawla R, Grover V, Ghosh S, et al. Guidelines for Periodontal Care Management of periodontal disease in patients with diabetes good clinical practice guidelines: A joint statement by Indian Society of Periodontology and Research Society for the Study of Diabetes in India. Journal of Indian Society of Periodontology. 2020;24(6):498-524. doi: 10.4103/jisp.jisp_688_20

13. Malicka B, Kaczmarek U, Skośkiewicz - Malinowska K. Prevalence of xerostomia and the salivary flow rate in diabetic patients. Adv Clin Exp Med. 2014; 23(2): 225-233. doi: 10.17219/acem/37067.

14. Orbak R, Simsek S, Orbak Z, Kavrut F, and Colak M. The influence of type-1 diabetes mellitus on dentition and oral health in children and adolescents. Yonsei Medical Journal. 2008;49(3):357–365. doi: 10.3349/ymi.2008.43.3.357

15. Twetman S, Petersson G, Bratthall D. Caries risk assessment as a predictor of metabolic control in young Type 1 diabetics. Diabetic Medicine. 2005;22(3):312-315. doi: 10.1111/j.1464-5491.2005.01419.x

16. Preshaw PM, Alba AL, Herrera D et al. Periodontitis and diabetes: a two-way relationship. Diabetologia. 2012;55(1):21–31. doi: 10.1007/s00125-011-2342-y.

17. Grover HS, Luthra S. Molecular mechanisms involved in the bidirectional relationship between diabetes mellitus and periodontal disease. Journal of Indian Society of Periodontology. 2013;17(3):292-301. doi: 10.4103/0972-124X.115642

18. Leontyev VK, Kiselnikova LP, editors. Pediatric dentistry. National Leadership. Moscow: GEOTAR-Media. 2010. 896 p. (In Russ.). Available from: https://www.elibrary.ru/item.asp?id=19552884

19. Kiselnikova LP, Alekseeva IA, Danilova IG, Gette IF, Ozhgikhina NV. The analysis of characteristics of phosphoric calcium metabolism in pathogenesis of caries in children of adolescent age. Medical Journal of the Russian Federation. 2014;20(2):27-30. doi: 10.17816/rmj38173

20. Kiselnikova LP, Alekseeva IA, Danilova IG, Kaminskaya LA. The study of the calcium and phosphorus metabolism impact on the development of demineralized enamel areas in adolescents. Pediatric dentistry and dental prophylaxis. 2021;21(3):216-220 (In Russ.). Available from: doi: 10.33925/1683-3031-2021-21-3-216-220

21. Orekhova LYu, Petrov AA, Loboda ES, Berezkina IV, Shadrina KV. Study of functional state of microcirculatory channel system in periodontal tissues in persons of different age groups. Pediatric dentistry and dental prophylaxis. 2020;20(2):88-94 (In Russ.). doi: 10.33925/1683-3031-2020-20-2-88-94

22. Orekhova LYu, Alexandrova AA, Silina ES, Musaeva RS, Posokhova EV. Periodontal status and effeciency of the individual oral hygiene complex in for prevention of inflammatory periodontal diseases in diabetes mellitus pregnant women . Parodontologiya. 2015;20(4):33–39 (In Russ.). Available from: https://www.elibrary.ru/item.asp?id=25615432

23. Aral CA, Nalbantoğlu Ö, Nur BG, Altunsoy M, Aral K. Metabolic control and periodontal treatment decreases elevated oxidative stress in the early phases of type 1 diabetes onset. Arch Oral Biol. 2017;82:115-120. doi: 10.1016/j.archoralbio.2017.06.009

24. Iordanishvili AK, Soldatova LN, Pereverzev VS, Zhmud MV, Zhmud ON. Dental health in children with type I diabetes mellitus and ways of its improvement. Ros Vestn Perinatol i Pediatr. 2017;62(1):121-126 (In Russ.). doi: 10.21508/1027–4065–2017–62–1–121–126

25. Ferizi L, Dragidella F, Spahiu L, Begzati A, Kotori V. The Influence of Type 1 Diabetes Mellitus on Dental Caries and Salivary Composition. International Journal of Dentistry. 2018;2018:5780916. Published 2018 Oct 2. doi: 10.1155/2018/5780916

26. Davydov BN, Domenyuk DA, Dmitrienko SV. Peculiarities of microcirculation in periodont tissues in children of key age groups sufficient type 1 diabetes. Part II. Parodontologiya. 2019;24(2):108-119 (In Russ.). doi: 10.33925/1683-3759-2019-24-2-108-119.

27. Davydov BN, Domenyk DA, Dmitrienko SV. Peculiarities of microcirculation in peridont tissues in children of key age groups sufficient type 1 diabetes. Part I. Parodontologiya. 2019;24(1):4-10 (In Russ.). doi: 10.25636/PMP.1.2019.1.1

28. Ivchenko LG, Bykov IM, Basov AA, Gilmiyarova FN, Domenyuk DA, Budaichiev GM-A, et. Development and justification of the estimation algorithm of the bone system metabolism in children with type 1 diabetes mellitus. Kubanskij nauchnyj medicinskij vestnik. 2018;25(5):35-47 (In Russ.). doi: 10.25207 / 1608-6228- 2018-25-5-35-47

29. Bykov IM, Gilmiyarova FN, Domenyuk DA, Dmitrienko SV, Ivanyuta SO, Budaychiev GM-A. Evaluation of cariogenic situation in children with type 1 diabetes mellitus given the mineralizing potential of saliva and enamel resistance. Kubanskij nauchnyj medicinskij vestnik. 2018;25(4):22-36 (In Russ.). doi: 10.25207 / 1608-6228-2018-25-4-22-36.

30. Davydov BN, Domenyuk DA, Samedov FV, Dmitrienko SV, Lepilin AV. Clinical and functional approaches to comprehensive treatment of periodontal diseases in children with type I diabetes. Parodontologiya. 2021;26(1):9-19 (In Russ.). doi: 10.33925/1683-3759-2021-26-1-9-19