Features of biochemical composition of oral fluid in patients with psychoneurological disorders

Abstract

Relevance. The development of high-tech methods of analysis of oral fluid, as well as the expansion of knowledge in the understanding of changes in its physical and chemical properties can increase the diagnostic value at the stage of preclinical manifestations. Materials and methods. The level of lysozyme activity, total protein concentration and proteolytic enzyme activity in the oral fluid of patients with psychoneurological disorders were studied. Results and discussion. The biochemical composition of oral fluid in patients with psychoneurological disorders is significantly different. Both metal-dependent and low-molecular serine proteases were found in the study material. The total activity of proteolytic enzymes in patients of this group is significantly higher (р ≤0.05) than in the comparison group. The level of lysozyme activity (10.2±0.32%) was significantly reduced in the oral fluid of patients with psychoneurological disorders, indicating a low degree of nonspecific resistance.