Microbiota of the oral cavity. Prospects for the use of bacteriophages complex for oral diseases prevention

Caries is one of the most common oral diseases in childhood. Its frequency in the structure of diseases in children reaches 100% in some age groups. However, existing prophylactic and therapeutic methods do not reduce this figure, and complications caused by caries remain at an unforgivably high level. According to researchers, the causes of inadequate «sanitation» of the oral cavity lie in a misunderstanding and disregard for the microbial composition of the oral biocenosis. It was been proven that imbalance of the oral microbiome induces not only caries, inflammatory periodontal diseases, oral mucosa, but also creates conditions for a wide range of somatic pathology, including allergic reactions. Expansion of indications for the use of antibacterial and antiseptic agents may provoke changes in the oral microbiota, both as result of direct effects on microorganisms and as result of immunosuppressive and cytotoxic effects.

микробиом, оральная микробиота, дентальная биопленка, кариес, заболевания пародонта, бактериофаг, фаг, фаготерапия, Фагодент, microbiome, oral microbiota, dental biofilm, caries, periodontal disease, bacteriophage, phage, phage therapy, Phagodent

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