Feasibility of microbial markers detection by chromato-mass-spectrometry in dentistry. Literature review

Relevance. The problem of the prevention and treatment of dental caries is one of the leading places in practical dentistry. Most likely, diseases of the hard tissues of the teeth are caused by multispecies communities of microorganisms. There fore, improving methods for identifying and identifying pathogens of dental diseases is relevant.

Purpose. To study the literature on the application of the method of chromatography-mass spectrometry of microbial markets in various fields of medicine.

Materials and methods. An analysis of 41 sources of literature on the etiology of pathogens of dental diseases and the results of the application of the method of chromatography-mass spectrometry of microbial markets in various fields of medicine was carried out.

Results. An analysis of the literature showed that the most common diseases of the oral cavity are most likely caused by multi-species communities, rather than individual isolated pathogenesis. When using bacteriological diagnostic methods, assessing the role of bacteria as an etiological and pathogenesis factor in the development and progression of destructive diseases of hard tissues teeth presents significant difficulties. The method of chromatography-mass spectrometry of microbial markets by the composition of microbial metabolites was used to study microbial communities involved in the development of various pathological processes, while the results were confirmed by inoculating samples of clinical material. As an additional method for diagnosing the state of the microflora of the oral cavity, the method of chromatography-mass spectrometry of microbial markets by the composition of microbial metabolites.

Conclusions. The possibility of detecting the causative agents of dental diseases by determining microbial communities by the method of chromatography-mass spectrometry of microbial markets was investigated and substantiated. The used of modern technologies for the identification of pathogens will make it possible in the future to clarify the etiology and pathogenesis, determine the range of pathogens, and will increase the effectiveness of treatment of dental diseases and reduce the cost of re-treatment.

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