Analysis of enamel hypoplasia causes and risk factors in children

Relevance. Enamel hypoplasia is one of the most common defects of a child's hard dental tissue. Molar incisor hypomineralization (MIH) is one of the systemic hypoplasia forms. MIH is defined as a qualitative defect of enamel development in children and adolescents affecting at least one permanent molar with or without the involvement of the incisors. As for the causes, MIH, as a form of enamel hypoplasia, proved to be a multifactorial disease.

Material and methods. Conducted in dental clinics of St. Petersburg, an empirical study surveyed 90 respondents with the anonymous original questionnaire developed by us. The report summarized the results of descriptive statistics on measurements related to the data of the three groups on existing disorders of the hard dental tissues in children.

Results. The average age of women whose children are not diagnosed with caries and enamel hypoplasia was 35.52 years, while the average age of mothers of children with MIH was 40.17 years. The study of the number of previous pregnancies and childbirths revealed no signs of MIH and pitting enamel hypoplasia (PET) in children of the first pregnancy. The analysis of the past medical history impact in women during pregnancy on the development of enamel defects provided statistically significant results for such illnesses as URTI and VURTI, as well as chronic endocrine diseases. According to the data obtained, influenza, past respiratory diseases and antibiotic intake during the first year of a child's life led to the development of various types of enamel hypoplasia.

1. Ozhgikhina NV, Zakirov TV, Ioschenko ES. Сaries intensity and rate of salivation in children with sistemic hypoplasia of enamel of permanent teeth. Modern problems of science and education. 2014;(5):533 (In Russ.). Available from: https://science-education.ru/ru/article/view?id=15227

2. Ozhgikhina NV, Zakirov TV, Kiselnikova LP. Need for treatment of enamel hypoplasia of the first permanent molars in children. Pediatric dentistry and dental prophylaxis. 2019;19(4):26-30. doi: 10.33925/1683-3031-2019-19-4-26-30

3. Ozhgikhina NV, Kiselnikova LP, Sheplyagina LA. Potentials for the endogenous prevention of caries in children with systemic hypoplasia of enamel of permanent teeth. Farmateka (In Russ.). Available from: https://pharmateca.ru/ru/archive/article/31676/

4. Weerheijm KL, Duggal M, Mejàre I, Papagiannoulis L, Koch G, Martens LC, et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent. 2003;4(3):110-113. Available from: https://pubmed.ncbi.nlm.nih.gov/14529329/

5. Wu X, Wang J, Li YH, Yang ZY, Zhou Z. Association of molar incisor hypomineralization with premature birth or low birth weight: systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2020;33(10):1700-1708. doi: 10.1080/14767058.2018.1527310

6. Lagarde M, Vennat E, Attal JP, Dursun E. Strategies to optimize bonding of adhesive materials to molarincisor hypomineralization-affected enamel: A systematic review. Int J Paediatr Dent. 2020;30(4):405-420. doi: 10.1111/ipd.12621

7. Kuzmina EM, Yanushevich OO, Kuzmina IN, Lapatina AV. Tendency in the prevalence of dental caries among the russian population over a 20-year period. Dental forum. 2020;(3):2-8 (In Russ.). Available from: https://elibrary.ru/item.asp?id=21357111

8. Ozhgikhina NV, Kiselnikova LP. Molar-incisal hypomineralization. Part 1: Etiology and clinical manifestations. Actual problems in dentistry. 2010;(3):40–43 (In Russ.). Available from: https://elibrary.ru/item.asp?id=16096145

9. Beentjes VE, Weerheijm KL, Groen HJ. Factors involved in the aetiology of molar-incisor hypomineralisation (MIH). Eur J Paediatr Dent. 2002;3(1):9-13. Available from: https://pubmed.ncbi.nlm.nih.gov/12871011/

10. Elfrink ME, Ghanim A, Manton DJ, Weerheijm KL. Standardised studies on Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM): a need. Eur Arch Paediatr Dent. 2015;16(3):247-55. doi: 10.1007/s40368-015-0179-7

11. Lygidakis NA, Garot E, Somani C, Taylor GD, Rouas P, Wong FSL. Best clinical practice guidance for clinicians dealing with children presenting with molarincisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document. Eur Arch Paediatr Dent. 2022;23(1):3-21. doi: 10.1007/s40368-021-00668-5

12. Zameer M, Birajdar SB. The 'mysterious aetiology' of molar incisor hypomineralisation. Eur Arch Paediatr Dent. 2022;23(6):987-988. doi: 10.1007/s40368-022-00743-5

13. Garot E, Rouas P, Somani C, Taylor GD, Wong F, Lygidakis NA. An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis. Eur Arch Paediatr Dent. 2022;23(1):23-38. doi: 10.1007/s40368-021-00646-x

14. Serna C, Vicente A, Finke C, Ortiz AJ. Drugs related to the etiology of molar incisor hypomineralization: A systematic review. J Am Dent Assoc. 2016;147(2):120-130. doi: 10.1016/j.adaj.2015.08.011

15. Taube F, Marczewski M, Norén JG. Deviations of inorganic and organic carbon content in hypomineralised enamel. J Dent. 2015;43(2):269-278. doi: 10.1016/j.jdent.2014.09.003