The level of immunoglobulin A in saliva depending on the presence and severity of early childhood caries
https://doi.org/10.33925/1683-3031-2020-20-4-304-309
Abstract
Relevance. Immune defense plays a significant role in early childhood caries (ECC) development in children. The aim of the research was to study the level of secretory immunoglobulin A (SIgA) in the saliva of the children depending on the presence and severity of early childhood caries.
Materials and methods. 225 children participated in the study: 60 1-2-year-olds (the 1st group) and 165 3-5-year-olds (the 2nd group). In the 1st group 2 subgroups (30 children each) were formed: caries free (CF-1) and with severe ECC (S-ECC-1). In the 2nd group 3 subgroups (55 children each) were formed: caries free (CF-2), with ECC (ECC-2) and severe ECC (S-ECC-2). SIgA in the saliva (g/l) was measured by «IgA SALIVA ELISA» kit. The program Statistica 6 was used for statistical analysis.
Results. SIgA levels in the saliva were 37.40 ± 1.77 and 10.00 ± 0.67 in the subgroups CF-1 and S-ECC-1 (p < 0.001), 36.77 ± 2.58, 20.67 ± 1.08 and 9.83 ± 0.38 in the subgroups CF-2, ECC-2 и S-ECC-2 respectively (p < 0.001). In the first and second groups significant strong inverse Pierson correlation (r = -0.7-0.8) was revealed between SIgA levels in the saliva and S-ECC presence in the children.
Conclusions. The level of SIgA in the saliva reflects children's susceptibility to caries. Significant strong inverse correlation was revealed between SIgA in the saliva and severe ECC in the children.
About the Authors
A. S. Osokina
Volgograd State Medical University
Russian Federation
Russian Federation
Osokina Anastasia S. - PHD, Associate Professor of Paediatric Dentistry Department.
Volgograd
E. E. Maslak
Volgograd State Medical University
Russian Federation
Russian Federation
Maslak Elena E. - PhD, MD, DSc, Professor of Pediatric Dentistry Department.
Volgograd
A. T. Yakovlev
Volgograd State Medical University
Russian Federation
Russian Federation
Yakovlev Anatoliy T. - PhD, MD, DSc, Professor, Head of Clinical Laboratory Diagnostics Department.
Volgograd
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For citations:
Osokina A.S., Maslak E.E., Yakovlev A.T. The level of immunoglobulin A in saliva depending on the presence and severity of early childhood caries. Pediatric dentistry and dental prophylaxis. 2020;20(4):304-309. (In Russ.) https://doi.org/10.33925/1683-3031-2020-20-4-304-309
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