Predictive assessment of clusterization of the oral mineral metabolism in mixed dentition

Relevance. The high incidence of dental caries in children remains relevant to the modern preventive dentistry. Many works have appeared in the recent years on the primary prevention of dental diseases in children based on the caries risk prediction. Thus, dental caries prognosis is relevant and requires further study to improve the methods of individual prevention in children.

Purpose - to determine predictors of the oral mineral exchange in the mixed dentition according to the results of the cluster analysis.

Materials and methods. A comprehensive clinical and laboratory examination of the oral metabolic processes was performed in 60 caries-resistant children with the mixed dentition aged from 7 to 12 years. Statistical analysis was performed using STATISTICA 8.0 software.

Results. The study revealed strong relationship between the individual clinical and laboratory predictors, determined the optimal set of predictors for classifying patients with different types of saliva microcrystallization, which is a prerequisite for the possible caries risk prognosis in mixed dentition.

Conclusions. The obtained data of the oral mineral metabolism predictors can help to plan the individual primary prevention programs in children during the active formation of the hard dental tissues and to create software to make preclinical diagnosis and prognosis of the subclinical carious process.

1. Distel, V.A., Skripkina, G.I. Caries. The problem is solvable. Statuspraesens. Pediatrics and neonatology. 2018;1(46):30-34. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=35446291.

2. Ekimov, E.V. Clinical and laboratory features of the course and conservative treatment of initial dental caries in children with various activity of the carious process: Diss. ... cand. med. Perm. 2017:197. (In Russ.). Available at: https://psma.ru/index.php?option=com_mtree&task=att_download&link_id=137&cf_id=24.

3. Ekimov, E.V., Skripkina, G.I. The incidence of initial tooth decay in Omsk children, taking into account the degree of activity of the pathological process. Institute of Dentistry. 2017;2(75):22-23. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=29436536.

4. Maslak, E.E., Fomenko, I.V. Development of paediatric dentistry service in volgograd region (in memory of Litovkina l. S.). Dentistry of children and prevention. 2020;2(74):154-155. (In Russ.). Available at: DOI: 10.33925/1683-3031-2020-20-2-154-155.

5. Alikberov, M.Kh. Optimization of the prevention of dental caries in military personnel in extreme conditions. Abstract. ... cand. med. sciences. Nizhny Novgorod. 2019:147 (In Russ.). Available at: http://ma.cfuv.ru/docs/240935/Афтореферат.pdf.

6. Birina, O.A. Monitoring of dental health indicators for students of the militia lyceum as a result of the implementation of a comprehensive prevention program: Diss. ... cand. med. Perm. 2015:164. (In Russ.). Available at: https://psma.ru/index.php?option=com_mtree&task=att_download&link_id=69&cf_id=24.

7. Brodina, T.V. Epidemiological features of the occurrence and spread of dental caries in children in St. Petersburg in the modern period: Diss. ... cand. med. sciences. St. Petersburg. 2018:134. (In Russ.). Available at: https://www.dissercat.com/content/epidemiologicheskie-osobennosti-voznikno-veniya-i-rasprostraneniya-kariesa-zubov-u-detei-v/read.

8. Byvaltseva, S.Yu. Prediction and prevention of caries of permanent teeth in children: Author. ... cand. med. sciences. Irkutsk. 2007:23. (In Russ.). Available at: https://new-disser.ru/_avtoreferats/01004035885.pdf.

9. Kamenskih, D.V. Clinical and experimental justification of pathogenetic therapy of early childhood caries: Diss. ... cand. med. sciences. Permian. 2018:153. (In Russ.). Available at: https://www.psma.ru/index.php?option=com_mtree&task=att_download&link_id=216&cf_id=24.

10. Ioshchenko, E.S. Prediction and individual prevention of dental caries in children: Abstract. ... cand. med. sciences. Yekaterinburg. 2010:23. (In Russ.). Available at: https://www.dissercat.com/content/prognozirovanie-i-in-dividualnaya-profilaktika-kariesa-zubov-u-detei/read.

11. Li Wei. Improving the effectiveness of the prevention of decay of temporary teeth by regulating the maturation of enamel: Abstract. ... cand. med. sciences. Moscow. 2019:25. (In Russ.). Available at: https://www.dissercat.com/content/povyshenie-effektivnosti-profilaktiki-karie-sa-vremennykh-zubov-putem-regulyatsii-protsessov/read.

12. Razmakhnina, E.M. Clinical and molecular genetic features of predicting and evaluating the effectiveness of caries prevention: Abstract. ... cand. med. sciences. Ekaterinburg. 2018:23 (In Russ.). Available at: https://www.dissercat.com/content/klinicheskie-i-molekulyarno-geneticheskie-osoben-nosti-prognozirovaniya-i-otsenki-effektivnos/read.

13. Rodionova, A.S. Comparative effectiveness of various oral hygiene products in the prevention of dental caries in young children: Abstract. ... cand. med. sciences. Volgograd. 2013:24. (In Russ.). Available at: https://www.disser-cat.com/content/sravnitelnaya-effektivnost-razlichnykh-sredstv-gigieny-polosti-rta-v-profilaktike-kariesa-zu/read.

14. Skripkina, G.I. Donosological diagnosis and prediction of the carious process in children (clinical and laboratory research, mathematical modeling): Diss. ... d-ra med. sciences. Omsk. 2012:443. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=22322117.

15. Safina, R.M. Clinical and experimental rationale for improving early prevention of dental caries in children: Diss. ... cand. med. sciences. Kazan. 2005:124 (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=16180089.

16. Lukashevich, I.K., Vardugina, O.K., Gorbunova, I.L. Substantiation of the choice of means for the prevention of caries in pregnant women, taking into account the frequency of polymorphism of the kallecrein-4 gene. Modern dentistry. 2018;2(39):39-40 (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=35290275.

17. Skripkina, G.I., Ekimov, E.V., Mityaeva, T.S. System approach to the problem of forecasting the caries of teeth. Pediatric dentistry, prevention and orthodontics. 2019;3(15):121-126 (In Russ.). Available at: DOI: 10.18481/2077-7566-2019-15-3-121 -126.

18. Okushko, V.R. Problem of caries in the coordinates of human biology and economics. Clinical Dentistry. 2012;3(63):30-36 (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=22473189.

19. Atara A.G., Manjusha R., Shukla V.J., Vaghela D.B., Rooparalia B. Clinical evaluation of Krimidanta Pratishedha (anti-caries) activity of Triphaladi Gandusha in high risk dental caries patients. Ayu. 2014;35(1):42-45. http://doi.org/10.4103/0974-8520.141916.

20. Trushevskaya, A.G. (red.) Dental examination: Basic methods. 3rd edition. Geneva. 1989:58. (In Russ.). Available at: http://brest.rsek.nlb.by/cgi-bin/koha/opac-detail.pl?biblionumber=78217.

21. Skripkina, G.I. Diagnosis of the level of oral health and prediction of dental caries in children. Omsk; 2014: 180 (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=25993793.

22. Skripkina, G.I., Khvostova, K.S., Weitz, S.V. The application of teeth hard tissue electrometry at children's. Pediatric dentistry and prophylaxis. 2010;2(33):23-25. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=14614754.

23. Leontyev, V.K. Caries and mineralization processes. Development of methodological approaches, molecular mechanisms, pathogenetic substantiation of the principles of prevention and treatment: Diss. ... d-ra med. sciences. Moscow. 1978:541 (In Russ.). Available at: https://search.rsl.ru/ru/record/01007800588.

24. Leontyev, V.K., Pitaeva, A.N., Skripkina, G.I., Adkina, G.V. Influence of the composition and properties of the oral fluid on the energy interaction in the enamel-saliva system. Materials of the XXIV International Jubilee Symposium „Innovative Technologies in Dentistry" dedicated to the 60th anniversary of the Faculty of Dentistry of Omsk State Medical University. 2017:240-243 (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=32365103.

25. Shirobokova, V.G. Clinical and biochemical characteristics of sediment of mixed saliva in a healthy oral cavity and with dental caries: Diss. . cand. med. sciences. Omsk. 1974:180. (In Russ.). Available at: https://search.rsl.ru/ru/record/01007099828.

26. Voloshina, I.M., Skripkina, G.I, Makarov, S.E., Pitaeva, A.N., Solonenko, A.P Mineralizing potential of oral fluid. Certificate of state registration of a computer program Russian Federation. №20155612583, published 24.02.15. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=39328211.

27. Belskaya, L.V., Golovanova, O.A., Shukailo, E.S. Crystallization of biological liquids: - prospects for use in diagnosis. Butlerov messages. 2010;15 (23):52-56 (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=15580271.

28. Leus, PA. Clinical and experimental study of pathology, pathogenetic conservative therapy and prevention of dental caries: Abstract ... d-ra med. sciences. Minsk. 1977:30. Available at: https://search.rsl.ru/ru/record/01007723448.

29. Puzikova, O.Yu. Predicting the development of dental caries taking into account integrated indicators and mathematical modeling: Diss. ... cand. med. sciences. Omsk. 1999:183. (In Russ.). Available at: https://rusneb.ru/catalog/000200_000018_RU_NLR_bibl_1390780/.

30. Borovikov, V.A. STATISTICA: the art of computer data analysis for professionals. - St. Petersburg. : 2001. 635. (In Russ.). Available at: https://search.rsl.ru/ru/record/01000713644.

31. Yuldashkhonova, A.S., Abdullaev, J.R., Khudanov, B.O., Khasanov, D.M. Evaluation of the effectiveness of the prevention of dental caries in children, based on methods for their prediction. Graduate student. 2012;51 (2.1):164-169. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=17685243.

32. Elovikova, T.M., Grigoriev, S.S. Saliva as a biological fluid and its role in oral health: Textbook, 2018: 136. (In Russ.). Available at: https://dental-press.ru/upload/dba7d3f2bf9300098986b1c541dec8b5/files/d19e1d3e-7ce3527b20c2abfda3b58deb.pdf.

33. Leus, PA. The European indicators for oral health: what they indicate? Modern dentistry. 2015;1(60):4-7. (In Russ.). Available at: https://elibrary.ru/item.asp?id=23137254.

34. Skripkina, G.I., Garifullina, A.Zh., Leus, P.A. European indicators of dental health for schoolchildren in Omsk. - Materials of the XXIV International Jubilee Symposium „Innovative Technologies in Dentistry" dedicated to the 60th anniversary of the Faculty of Dentistry of Omsk State Medical University. 2017:449-451. (In Russ.). Available at: https://www.elibrary.ru/item.asp?id=32365167.

35. Skripkina, G.I., Ekimov, E.V., Nikitin, Yu.B., Korunov, A.P., Bernetsyan, T.L. Quantitative assessment of the level of mineralizing potential of oral fluid in children. Problems of dentistry. 2020;16(1):127-132 (In Russ.). Available at: DOI: 10.18481/2077-7566-20-16-1-127-132.