Periodontopathogens: a new view. Systematic review. Part 2
https://doi.org/10.33925/1683-3031-2020-20-2-160-167
Abstract
Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review.
Purpose. To study a new paradigm of development of generalized periodontitis.
Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years.
Results. The transition from a symbiotic microflora to a dysbiotic pathogenic community triggers the host's inflammatory response, which contributes to the development of periodontal diseases. Modern ideas about periodontal pathogenic bacteria dictate new requirements for the treatment of periodontal diseases. The second part of the review examines the microbial profiles of periodontal disease in various nosological forms, the mechanisms of the immune response and approaches to the treatment of periodontal disease from the perspective of biofilm infection.
Conclusions. As follows from modern literature periodontitis is to a certain extent caused by the transition from a harmonious symbiotic bacterial community to a dysbiotic one. Recent scientific studies have shown that not single microorganism is not able to cause disease but the microbial community as a whole leads to the development of pathology.
About the Authors
E. S. Slazhneva
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation
Russian Federation
Slazhneva Ekaterina S., MD, post-graduate student of the Department of Periodontology
Moscow
E. A. Tikhomirova
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation
Russian Federation
Tikhomirova Ekaterina A., MD, post-graduate student of the Department of Periodontology
Moscow
V. G. Atrushkevich
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation
Russian Federation
Atrushkevich Victoria G., DSc, Professor of the Department of Periodontology, Vice-President of RPA
Moscow
References
1. B. T. Rosier, P. D. Marsh, A. Mira. Resilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis. J Dent Res. 2018;Apr;97(4):371-380. https://doi.org/10.1177/0022034517742139.
2. M. Zarco, T. Vess, G. Ginsburg. The oral microbiome in health and disease and the potential impactonpersonalized dental medicine. Oral Dis;2012;18(2):109-120. https://doi.org/10.1111/j.1601-0825.2011.01851.x.
3. C. D. Long, G. C. Armitage. Bacterial diversity in the oral cavity of 10 healthy individuals. ISME J. 2010;4(8):962/ https://doi.org/10.1038/ismej.2010.30.
4. M. Wiernicka-Menkiszak, E. Dembowska. Localized. Aggressive Periodontitis – Diagnostics, Epidemiology, Etiopathogenesis. Dent Med Probl. 2012;49(4):567-575. https://journals.indexcopernicus.com/search/article?articleId=542288.
5. V. Meuric, S. Le Gall-David. Signature of Microbial Dysbiosis in Periodontitis. Appl Environ Microbiol. 2017;30;83(14). https://doi.org/10.1128/AEM.00462-17.
6. C. Y. Tang, T. Tan, K. Chen. et al. Subgingival microbiota in individuals with severe chronic periodontitis. Journal of microbiology, immunology, and infection. 2018;Apr;51(2):226-234. https://doi.org/10.1016/j.jmii.2016.04.007.
7. P. Wang, D. Duan, X. Zhou et al. Relationship between expression of human gingival beta-defensins and levels of periodontopathogens in subgingival plaque. J Periodont Res. 2015;50:113-122. https://doi.org/10.1111/jre.12187.
8. V. T. Dosseva-Panova, C. L. Popova, V. E. Panov. Subgingival microbial profile and production of proinflammatory cytokines in chronic periodontitis. Folia medica. 2014;56(3):152-160. https://doi.org/10.2478/folmed-2014-0022.
9. R. J. Lamont, H. Koo, G. Hajishengallis. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 2018;Dec;16(12):745-759. https://doi.org/10.1038/s41579-018-0089-x.
10. X. Yong, Y. Chen, R. Tao et al. Periodontopathogens and human b-defensin-2 expression in gingival crevicular fluid from patients with periodontal disease in Guangxi, China. J Periodont Res. 2015;Jun;50(3):403-410. https://doi.org/10.1111/jre.12220.
11. M. Asad, A. W. Abdul Aziz, R. P. Raman et al. Comparison of nonsurgical periodontal therapy with oral hygiene instruction population alone for chronic periodontitis. J Oral Sci. 2017;59(1):111-120. https://doi.org/10.2334/josnusd.16-0298.
12. K. Torrungruang, S. Jitpakdeebordin, O. Charatkulangkun et al. Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema denticola/ Prevotella intermedia co-infection are associated with severe periodontitis in a thai. PLoS One. 2015;Aug;27;10(8):e0136646. https://doi.org/10.1371/journal.pone.0136646.
13. S. A. Mosaddad, E. Tahmasebi. Oral microbial biofilms: an update. Eur J Clin Microbiol Infect Dis. 2019;Nov;38(11):2005-2019. https://doi.org/10.1007/s10096-019-03641-9.
14. X. Xu, Z. Wang, X. Zhang. The human microbiota associated with overall health. Crit Rev Biotechnol. 2015;Mar;35(1):129-140. https://doi.org/10.3109/07388551.2013.819485.
15. U. Shet, H. K. Oh, H. J. Chung et al. Humoral immune responses to periodontal pathogens in the elderly. J Periodontal Implant Sci. 2015;Oct;45(5):178-183. https://doi.org/10.5051/jpis.2015.45.5.178.
16. G. S. Pashkova, D. T. Galieva, K. E. Isadzhanyan, V. V. Nikitin, V. M. Popova, E. L. Zhilenkov. Osobennosti mikroflory polosti rta u pacientov s vospalitel'nymi zabolevaniyami parodonta. Lechenie i profilaktika. 2013;4:71-76. (In Russ.). https://apluspha.nethouse.ru/static/doc/0000/0000/0272/272025.krdm28ie4w.pdf.
17. M. M. Usin, S. M. Tabares, J. Menso et al. Generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy.Acta Odontol. Latinoam. 2016;Dec;29(3):255-226. http://www.scielo.org.ar/pdf/aol/v29n3/v29n3a09.pdf.
18. J. R. Collins, S. Chinea, R. J. Cuello et al. Subgingival microbiological profile of periodontitis patients in Dominican Republic. Acta Odontol Latinoam. 2019;Apr;1;32(1):36-43. http://www.scielo.org.ar/pdf/aol/v32n1/v32n1a06.pdf.
19. K. Y. How, K. P. Song. Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line. Front Microbiol. 2016;Feb;9;7:53. https://doi.org/10.3389/fmicb.2016.00053.
20. M. H. Salari, Z. Kadkhoda. Rate of cultivable subgingival periodontopathogenic bacteria in chronic periodontitis. J Oral Sci. 2004;Sep;46(3):157-161. https://doi.org/10.2334/josnusd.46.157.
21. M. Gołyńska, I. Polkowska, M. BartoszczeTomaszewska et al. Molecular-level evaluation of selected periodontal pathogens from subgingival regions in canines and humans with periodontal disease. J Vet Sci. 2017;Mar;18(1):51-58. https://doi.org/10.4142/jvs.2017.18.1.51.
22. L. Nibali, F. D’Aiuto, D. Ready et al. No association between A.actinomycetemcomitans or P. gingivalis and chronic or aggressive periodontitis diagnosis. Quintessence Int. 2012;43(3):247-254. https://qi.quintessenz.de/index.php?doc=abstract&abstractID=22763/.
23. J. L. Ebersole, D. 3rd Dawson. The periodontal war: microbes and immunity Periodontology 2000. 2017;75:52-115. https://doi.org/10.1111/prd.12222.
24. S. C. Holt, J. L. Ebersole. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the “red complex“, a prototype polybacterial pathogenic consortium in periodontitis. Periodontology 2000. 2005;38:72-122. https://doi.org/10.1111/j.1600-0757.2005.00113.x.
25. H. M. Ng, L. X. Kin. Bacterial interactions in pathogenic subgingival plaque. Microbial Pathogenesis. 2016;May;94:60-69. https://doi.org/10.1016/j.micpath.2015.10.022.
26. L. Scapoli, A. Girardi, A. Palmieri et al. Quantitative analysis of periodontal pathogens in periodontitis and gingivitis. J Biol Regul Homeost Agents. 2015;Jul-Sep;29(3 Suppl1):101-110. https://www.ncbi.nlm.nih.gov/pubmed/26511188.
27. A. Mira, A. Simon-Soro, M. A. Curtis. Role of microbialcommunitiesinthepathogenesisofperiodontal diseases and caries. J Clin Periodontol. 2017;Mar;44; 18:S23-S38. https://doi.org/10.1111/jcpe.12671.
28. A. M. Frey, M. J. Satur. Characterization of Porphyromonas gingivalis sialidase and disruption of its role in host-pathogen interactions. Microbiology. 2019;Nov;165(11):1181-1197. https://doi.org/10.1099/mic.0.000851.
29. A. P. V. Colombo, A. C. R. Tanner. The Role of Bacterial Biofilms in Dental Caries and Periodontal and Peri-implant Diseases: A Historical Perspective. J Dent Res. 2019;Apr;98(4):373-385. https://doi.org/10.1177/0022034519830686.
30. B. Retamal-Valdes, M. C. Formiga. Does subgingival bacterial colonization differ between implants and teeth? A systematic review. Braz Oral Res.2019;30;33(1):e064. https://doi.org/10.1590/1807-3107bor-2019.vol33.0064.
31. S. U. Gorr. Antimicrobial peptides in periodontal innate defense.Front Oral Biol. 2012;15:84-98. https://doi.org/10.1159/000329673.
32. F. A. Roberts, R. P. Darveau. Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontol 2000. 2015;Oct;69(1):18-27. https://doi.org/10.1111/prd.12087.
33. M. Feres. Systemic antibiotics in the treatment of periodontitis. Periodontology 2000. 2015;67(1): 131-186. https://doi.org/10.1111/prd.12075.
Review
For citations:
Slazhneva E.S., Tikhomirova E.A., Atrushkevich V.G. Periodontopathogens: a new view. Systematic review. Part 2. Pediatric dentistry and dental prophylaxis. 2020;20(2):160-167. (In Russ.) https://doi.org/10.33925/1683-3031-2020-20-2-160-167
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