<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detstom</journal-id><journal-title-group><journal-title xml:lang="ru">Стоматология детского возраста и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric dentistry and dental prophylaxis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3031</issn><issn pub-type="epub">1726-7218</issn><publisher><publisher-name>RPA</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3031-2024-851</article-id><article-id custom-type="elpub" pub-id-type="custom">detstom-851</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Глубина проникновения ионов серебра в дентин после обработки кариозной полости диаминфторидом серебра</article-title><trans-title-group xml:lang="en"><trans-title>Depth of silver ion penetration into dentin following treatment of carious lesions with silver diamine fluoride</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-6137-1449</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Животова</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhivotova</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Животова Виктория Михайловна, аспирант кафедры стоматологии детского возраста</p><p>400066, пл-дь Павших Борцов, д. 1, г. Волгоград</p></bio><bio xml:lang="en"><p>Victoria M. Zhivotova, DMD, PhD student, Department of the Pediatric Dentistry</p><p>1 Pavshih Bortsov Sq., Volgograd, 400066</p></bio><email xlink:type="simple">vikiku12@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2011-9714</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маслак</surname><given-names>Е. E.</given-names></name><name name-style="western" xml:lang="en"><surname>Maslak</surname><given-names>E. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маслак Елена Ефимовна, доктор медицинских наук, профессор кафедры стоматологии детского возраста</p><p>Волгоград</p></bio><bio xml:lang="en"><p>Elena E. Maslak, DMD, PhD, DSc, Professor, Department of the Pediatric Dentistry</p><p>Volgograd</p></bio><email xlink:type="simple">eemaslak@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2192-5913</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гайдадин</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaidadin</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гайдадин Алексей Николаевич, кандидат технических наук, доцент кафедры химии и технологии переработки эластомеров</p><p>Волгоград</p></bio><bio xml:lang="en"><p>Alexei N. Gaidadin, PhD, Associate Professor, Department of Chemistry and Elastomer Processing Technology</p><p>Volgograd</p></bio><email xlink:type="simple">lit@vstu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3805-6977</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуревич</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gurevich</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гуревич Леонид Моисеевич, доктор технических наук, заведующий кафедрой материаловедения и композиционных материалов</p><p>Волгоград</p></bio><bio xml:lang="en"><p>Leonid M. Gurevich, PhD, DSc, Head of the Department of Materials Science and Composite Materials</p><p>Volgograd</p></bio><email xlink:type="simple">mv@vstu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Волгоградский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Волгоградский государственный технический университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Technical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2025</year></pub-date><volume>24</volume><issue>4</issue><fpage>352</fpage><lpage>357</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Животова В.М., Маслак Е.E., Гайдадин А.Н., Гуревич Л.М., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Животова В.М., Маслак Е.E., Гайдадин А.Н., Гуревич Л.М.</copyright-holder><copyright-holder xml:lang="en">Zhivotova V.M., Maslak E.E., Gaidadin A.N., Gurevich L.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.detstom.ru/jour/article/view/851">https://www.detstom.ru/jour/article/view/851</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Для лечения кариеса у детей раннего возраста специалисты стремятся применять неинвазивные методы, чтобы сократить время лечения и избежать возникновения неприятных ощущений и боли, ведущих к формированию стоматофобии. Одним из известных неинвазивных методов лечения кариеса дентина временных зубов является применение препаратов диаминфторида серебра (ДФС), однако мало изученным остается вопрос распространения компонентов препарата в кариозном и здоровом дентине.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: определение глубины инфильтрации дентина ионами серебра после обработки ДФС кариозных полостей временных зубов.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Исследование in vitro проводилось на 6 удаленных временных зубах с кариозными полостями. Кариозные ткани обрабатывали препаратом ДФС отечественного производства. Микрошлифы зубов изучались с помощью качественного и количественного микрорентгеноконтрастного анализа, оптического микроскопа и сканирующего электронного микроскопа с детектором элементного анализа.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что глубина проникновения ионов серебра составляла от 48,30 ± 9,43 до 875,00 ± 35,76 микрон и соответствовала глубине кариозного и деминерализованного дентина. Концентрация серебра увеличивалась по направлению от поверхности в глубину кариозного поражения и достигала максимума в деминерализованном слое вблизи кариозного дентина. В здоровом дентине ионы серебра не выявлены.</p></sec><sec><title>Заключение</title><p>Заключение. После обработки кариозных полостей временных зубов ДФС ионы серебра инфильтрируют кариозную ткань на всю глубину, достигая наибольшей концентрации в деминерализованном слое дентина и не проникая в здоровый дентин.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Non-invasive methods are favoured for treating early childhood caries to reduce treatment time and prevent discomfort or pain, which can lead to dental anxiety. Among the well-established non-invasive approaches for managing dentinal caries in primary teeth is the application of silver diamine fluoride (SDF). However, the extent to which SDF components diffuse into carious and sound dentin remains insufficiently studied. This study aimed to evaluate the depth of dentin infiltration by silver ions after SDF treatment of carious lesions in primary teeth.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. An in vitro study was performed on six extracted primary teeth with carious lesions, which were treated using a domestically produced SDF preparation. Tooth microsections were analyzed through qualitative and quantitative micro-X-ray analysis, optical microscopy, and scanning electron microscopy equipped with elemental analysis detectors.</p></sec><sec><title>Results</title><p>Results. The depth of silver ion penetration varied from 48.30 ± 9.43 µm to 875.00 ± 35.76 µm, aligning with the depth of carious and demineralized dentin. The silver concentration progressively increased from the surface to the deeper layers of the carious lesion, reaching its peak in the demineralized layer adjacent to the carious dentin. No silver ions were detected in sound dentin.</p></sec><sec><title>Conclusion</title><p>Conclusion. Following SDF treatment of carious lesions in primary teeth, silver ions fully infiltrated the carious tissue, with the highest concentration observed in the demineralized dentin layer, while sound dentin remained unaffected.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>кариес временных зубов</kwd><kwd>диаминфторид серебра</kwd><kwd>проникновение ионов серебра в дентин</kwd><kwd>in vitro</kwd></kwd-group><kwd-group xml:lang="en"><kwd>primary tooth caries</kwd><kwd>silver diamine fluoride</kwd><kwd>silver ion penetration into dentin</kwd><kwd>in vitro</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Uribe SE, Innes N, Maldupa I. The global prevalence of early childhood caries: A systematic review with meta-analysis using the WHO diagnostic criteria. Int J Paediatr Dent. 2021;31(6):817-830. doi: 10.1111/ipd.12783</mixed-citation><mixed-citation xml:lang="en">Uribe SE, Innes N, Maldupa I. The global prevalence of early childhood caries: A systematic review with meta-analysis using the WHO diagnostic criteria. Int J Paediatr Dent. 2021;31(6):817-830. doi: 10.1111/ipd.12783</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">BaniHani A, Santamaría RM, Hu S, Maden M, Albadri S. Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review. Eur Arch Paediatr Dent. 2022;23(5):667-693. doi: 10.1007/s40368-021-00675-6</mixed-citation><mixed-citation xml:lang="en">BaniHani A, Santamaría RM, Hu S, Maden M, Albadri S. Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review. Eur Arch Paediatr Dent. 2022;23(5):667-693. doi: 10.1007/s40368-021-00675-6</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng FM, Yan IG, Duangthip D, Gao SS, Lo ECM, Chu CH. Silver diamine fluoride therapy for dental care. Jpn Dent Sci Rev. 2022;58:249-257. doi: 10.1016/j.jdsr.2022.08.001.</mixed-citation><mixed-citation xml:lang="en">Zheng FM, Yan IG, Duangthip D, Gao SS, Lo ECM, Chu CH. Silver diamine fluoride therapy for dental care. Jpn Dent Sci Rev. 2022;58:249-257. doi: 10.1016/j.jdsr.2022.08.001.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Seifo N, Robertson M, MacLean J, Blain K, Grosse S, Milne R, et al. The use of silver diamine fluoride (SDF) in dental practice. Br Dent J. 2020;228(2):75-81. doi: 10.1038/s41415-020-1203-9</mixed-citation><mixed-citation xml:lang="en">Seifo N, Robertson M, MacLean J, Blain K, Grosse S, Milne R, et al. The use of silver diamine fluoride (SDF) in dental practice. Br Dent J. 2020;228(2):75-81. doi: 10.1038/s41415-020-1203-9</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Куркина ОН, Маслак ЕЕ, Осокина АС, Хмызова ТГ, Куркина ВМ. Диаминфторид серебра для стабилизации кариеса зубов: результаты исследований in vitro (обзор литературы). Институт стоматологии. 2020;(1):95. Режим доступа: https://elibrary.ru/item.asp?id=43932842</mixed-citation><mixed-citation xml:lang="en">Kurkina ON, Maslak EE, Osokina AS, Khmizova TG, Kurkina VM. Silver diamine fluoride for caries arrest: the results of studies in vitro (literature review). The Dental Institute. 2020;1(86):95 (In Russ.). Available from: https://elibrary.ru/item.asp?id=43932842</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Yan IG, Zheng FM, Gao SS, Duangthip D, Lo ECM, Chu CH. Ion Concentration of silver diamine fluoride solutions. Int Dent J. 2022;72(6):779-784. doi: 10.1016/j.identj.2022.04.005</mixed-citation><mixed-citation xml:lang="en">Yan IG, Zheng FM, Gao SS, Duangthip D, Lo ECM, Chu CH. Ion Concentration of silver diamine fluoride solutions. Int Dent J. 2022;72(6):779-784. doi: 10.1016/j.identj.2022.04.005</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mei ML, Lo ECM, Chu CH. Arresting dentine caries with silver diamine fluoride: what's behind it? J Dent Res. 2018;97(7):751-758. doi: 10.1177/0022034518774783</mixed-citation><mixed-citation xml:lang="en">Mei ML, Lo ECM, Chu CH. Arresting dentine caries with silver diamine fluoride: what's behind it? J Dent Res. 2018;97(7):751-758. doi: 10.1177/0022034518774783</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kaur M, Shahid S, Karpukhina N, Anderson P, Wong FSL. Characterization of chemical reactions of silver diammine fluoride and hydroxyapatite under remineralization conditions. Front Oral Health. 2024;5:1332298. doi: 10.3389/froh.2024.1332298</mixed-citation><mixed-citation xml:lang="en">Kaur M, Shahid S, Karpukhina N, Anderson P, Wong FSL. Characterization of chemical reactions of silver diammine fluoride and hydroxyapatite under remineralization conditions. Front Oral Health. 2024;5:1332298. doi: 10.3389/froh.2024.1332298</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kaur M, Anderson P, Shahid S, Wong FSL. Chemical kinetics of silver diammine fluoride in demineralization and remineralization solutions-an in vitro study. Front Oral Health. 2024;5:1374333. doi: 10.3389/froh.2024.1374333</mixed-citation><mixed-citation xml:lang="en">Kaur M, Anderson P, Shahid S, Wong FSL. Chemical kinetics of silver diammine fluoride in demineralization and remineralization solutions-an in vitro study. Front Oral Health. 2024;5:1374333. doi: 10.3389/froh.2024.1374333</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y, Liu Y, Psoter WJ, Nguyen OM, Bromage TG, Walters MA, et al. Assessment of the silver penetration and distribution in carious lesions of deciduous teeth treated with silver diamine fluoride. Caries Res. 2019;53(4):431-440. doi: 10.1159/000496210</mixed-citation><mixed-citation xml:lang="en">Li Y, Liu Y, Psoter WJ, Nguyen OM, Bromage TG, Walters MA, et al. Assessment of the silver penetration and distribution in carious lesions of deciduous teeth treated with silver diamine fluoride. Caries Res. 2019;53(4):431-440. doi: 10.1159/000496210</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mulder R, Potgieter N, Noordien N. Penetration of SDF and AgF from the infected dentine towards the unaffected tooth structure. Front Oral Health. 2023;4:1298211. doi: 10.3389/froh.2023.1298211</mixed-citation><mixed-citation xml:lang="en">Mulder R, Potgieter N, Noordien N. Penetration of SDF and AgF from the infected dentine towards the unaffected tooth structure. Front Oral Health. 2023;4:1298211. doi: 10.3389/froh.2023.1298211</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
