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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detstom</journal-id><journal-title-group><journal-title xml:lang="ru">Стоматология детского возраста и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric dentistry and dental prophylaxis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3031</issn><issn pub-type="epub">1726-7218</issn><publisher><publisher-name>RPA</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3031-2024-804</article-id><article-id custom-type="elpub" pub-id-type="custom">detstom-804</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Изменение уровня тяжелых металлов в ротовой жидкости у молодых пациентов с брекет-системой  с развившимся катаральным гингивитом и без него</article-title><trans-title-group xml:lang="en"><trans-title>Changes in heavy metal levels in the oral fluid  of young patients with and without plaque-induced gingivitis undergoing treatment with braces</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4333-5735</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косырева</surname><given-names>Т. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosyreva</surname><given-names>T. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Косырева Тамара Федоровна, доктор медицинских наук, профессор кафедры стоматологии детского возраста и ортодонтии Медицинского института</p><p>Москва</p></bio><bio xml:lang="en"><p>Tamara F. Kosyreva, DMD, PhD, DSc, Professor, Department of the Pediatric Dentistry and Orthodontics, Medical Institute</p><p>Moscow </p></bio><email xlink:type="simple">kosyreva-tf@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9145-4435</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горшунова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorshunova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горшунова Наталья Викторовна, аспирант кафедры стоматологии детского возраста и ортодонтии Медицинского института</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia V. Gorshunova, DMD, PhD Student, Deparment of the Pediatric Dentistry and Orthodontics, Medical Institute</p><p>Moscow </p></bio><email xlink:type="simple">speciallyfornatalia@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4591-7694</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Катбех</surname><given-names>И.</given-names></name><name name-style="western" xml:lang="en"><surname>Katbeh</surname><given-names>I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Катбех Имад, кандидат медицинских наук, доцент кафедры стоматологии детского возраста и ортодонтии Медицинского института</p><p>Москва</p></bio><bio xml:lang="en"><p>Imad Katbeh, DMD, PhD, Associate Professor, Department of the Pediatric Dentistry and Orthodontics, Medical Institute</p><p>Moscow </p></bio><email xlink:type="simple">katbeh@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4113-6348</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абакелия</surname><given-names>К.</given-names></name><name name-style="western" xml:lang="en"><surname>Abakeliya</surname><given-names>K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абакелия Кама, кандидат медицинских наук, ассистент кафедры стоматологии детского возраста и ортодонтии Медицинского института</p><p>Москва</p></bio><bio xml:lang="en"><p>Kama Abakeliya, DMD, PhD, Assistant Professor, Department of the Pediatric Dentistry and Orthodontics, Medical Institute</p><p>Moscow </p></bio><email xlink:type="simple">kamaabakeliya@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5216-614X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аль Окби</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Al Okbi</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аль Окби Мустафа Азхар, аспирант кафедры стоматологии детского возраста и ортодонтии</p><p>Москва</p></bio><bio xml:lang="en"><p>Mustafa A. Al Okbi, DMD, PhD student, Department of the Pediatric Dentistry and Orthodontics, Medical Institute</p><p>Moscow </p></bio><email xlink:type="simple">Elu.fleurir@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3279-4119</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Альхамза</surname><given-names>Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Lhamza</surname><given-names>G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Альхамза Гарави, аспирант кафедры стоматологии детского возраста и ортодонтии</p><p>Москва</p></bio><bio xml:lang="en"><p>Gharawi Alhamza, DMD, PhD student, Department of the Pediatric Dentistry and Orthodontics, Medical Institute</p><p>Moscow </p></bio><email xlink:type="simple">alhamza.m@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples' Friendship University of Russia named after Patrice Lumumba</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2024</year></pub-date><volume>24</volume><issue>3</issue><fpage>284</fpage><lpage>297</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Косырева Т.Ф., Горшунова Н.В., Катбех И., Абакелия К., Аль Окби М.А., Альхамза Г., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Косырева Т.Ф., Горшунова Н.В., Катбех И., Абакелия К., Аль Окби М.А., Альхамза Г.</copyright-holder><copyright-holder xml:lang="en">Kosyreva T.F., Gorshunova N.V., Katbeh I., Abakeliya K., Al Okbi M.A., lhamza G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.detstom.ru/jour/article/view/804">https://www.detstom.ru/jour/article/view/804</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Актуальность. Оценка влияния никель-титановых сплавов и ионов тяжелых металлов на развитие воспалительных заболеваний полости рта становится крайне важным и необходимым направлением исследований в ортодонтии. Связь токсических элементов с воспалительными реакциями остается недостаточно хорошо изученной и противоречивой. Данные о связи тяжелых металлов с воспалительными реакциями могут влиять на выбор материала ортодонтического аппарата, а также на дальнейшее ведение пациентов с установленными конструкциями. Вопрос о безопасной эксплуатации металлической брекетсистемы из никель-титановых сплавов остается актуальным.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: определить уровни тяжелых металлов в ротовой жидкости у молодых пациентов с брекет-системой с развившимся катаральным гингивитом и без него.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Было отобрано 50 практически здоровых пациентов (I, II группа здоровья) с интактными зубами, a также имеющих компенсированную форму кариеса (единичные кариозные поражения – I степень кариеса) без патологии пародонта (индекс РМА &lt;20) с сужением и скученностью зубов (К07.2, К07.3), средний возраст 22,1 ± 2,7 лет, лечившихся металлической брекет-системой. У каждого пациента изучали 12 элементов тяжелых металлов в ротовой жидкости в лаборатории методом масс-спектрометрии с индуктивно связанной плазмой (ИСП-МС), а также активность лизоцима и рН ротовой жидкости до наложения аппаратуры и через шесть месяцев ортодонтической коррекции.</p></sec><sec><title>Результаты</title><p>Результаты. Адаптация молодых пациентов к лечению брекетами часто осложняется гингивитами и пародонтитами из-за ухудшения гигиены полости рта и давления на зубы и десны. Это приводит к дисэлементозам. Молодые пациенты с хроническим гингивитом при лечении брекетами находятся в группе риска по дисэлементозам и нуждаются в своевременной коррекции минерального обмена.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Research into the effects of nickel-titanium alloys and heavy metal ions on the development of inflammatory oral diseases is becoming increasingly significant in orthodontics. The relationship between toxic elements and inflammatory responses remains under-researched and controversial. Data on the connection between heavy metals and inflammatory reactions could influence the choice of orthodontic appliance materials and guide the subsequent management and monitoring of patients with braces. The question of the safe use of nickel-titanium alloy braces continues to be a relevant concern.</p></sec><sec><title>Purpose</title><p>Purpose. To assess the levels of heavy metals in the oral fluid of young patients with braces, both in those who developed plaque-induced gingivitis and those who did not.</p></sec><sec><title>Materials and Methods</title><p>Materials and Methods. The study involved 50 clinically healthy patients (Groups I and II health categories) with intact teeth, including patients with compensated dental caries (isolated carious lesions – Grade I) and no periodontal diseases (PMA index &lt;20), presenting with dental crowding and malocclusion (K07.2, K07.3). The average age of the patients was 22.1 ± 2.7 years, all of whom were undergoing treatment with metal braces. Oral fluid samples were analyzed for 12 heavy metal elements using inductively coupled plasma mass spectrometry (ICP-MS) in a laboratory setting. Additionally, lysozyme activity and oral fluid pH were measured before appliance placement and six months into orthodontic treatment.</p></sec><sec><title>Results</title><p>Results. Adaptation to braces in young patients is frequently complicated by the development of gingivitis and periodontitis due to impaired oral hygiene and the mechanical pressure exerted on teeth and gums, leading to elemental imbalances. Patients with gingivitis during orthodontic treatment are particularly at risk of developing such imbalances and therefore require timely correction of their mineral metabolism.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>стоматологический статус</kwd><kwd>масс-спектрометрия с индуктивно связанной плазмой</kwd><kwd>ионы тяжелых металлов</kwd><kwd>химические элементы</kwd><kwd>ротовая жидкость</kwd><kwd>рН</kwd><kwd>лизоцим</kwd><kwd>гингивит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oral health status</kwd><kwd>inductively coupled plasma mass spectrometry</kwd><kwd>heavy metal ions</kwd><kwd>chemical elements</kwd><kwd>oral fluid</kwd><kwd>pH</kwd><kwd>lysozyme</kwd><kwd>gingivitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тихонов ВЭ, Митин НЕ, Гришин МИ. 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