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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detstom</journal-id><journal-title-group><journal-title xml:lang="ru">Стоматология детского возраста и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric dentistry and dental prophylaxis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3031</issn><issn pub-type="epub">1726-7218</issn><publisher><publisher-name>RPA</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3031-2025-797</article-id><article-id custom-type="elpub" pub-id-type="custom">detstom-797</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Применение пробиотиков для лечения и профилактики заболеваний полости рта</article-title><trans-title-group xml:lang="en"><trans-title>Application of probiotics for the treatment and prevention of oral diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2232-8870</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Постников</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Postnikov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Постников Михаил Александрович, доктор медицинских наук, профессор, заведующий кафедрой терапевтической стоматологии</p><p>Самара</p></bio><bio xml:lang="en"><p>Mikhail A. Postnikov, DMD, PhD, DSc, Professor, Head of the Department of Operative Dentistry</p><p>Samara</p></bio><email xlink:type="simple">m.a.postnikov@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0334-8593</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Винник</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinnik</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Винник Анастасия Вячеславовна, ассистент кафедры терапевтической стоматологии</p><p>Самара</p></bio><bio xml:lang="en"><p>Anastasia V. Vinnik, DMD, Assistant Professor, Department of Operative Dentistry</p><p>Samara</p></bio><email xlink:type="simple">a.v.vinnik@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6104-3528</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костионова-Овод</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostionova-Ovod</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Костионова-Овод Ирина Анатольевна, кандидат медицинских наук, ассистент кафедры терапевтической стоматологии</p><p>Самара</p></bio><bio xml:lang="en"><p>Irina A. Kostionova-Ovod, DMD, PhD, Assistant Professor, Department of Operative Dentistry</p><p>Samara</p></bio><email xlink:type="simple">i.a.kostionova-ovod@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-1093-8903</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Апполонова</surname><given-names>Ю. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Appolonova</surname><given-names>Y. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Апполонова Юлия Юрьевна, студентка 5 курса Института стоматологии</p><p>Самара</p></bio><bio xml:lang="en"><p>Yulia Yu. Appolonova, 5th-year Student, Dental Institute</p><p>Samara</p></bio><email xlink:type="simple">yuliappolonova2511@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-8103-1990</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдина</surname><given-names>Я. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudina</surname><given-names>Y. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юдина Яна Сергеевна, студентка 5 курса Института стоматологии</p><p>443099, ул. Чапаевская, д. 89, г. Самара</p></bio><bio xml:lang="en"><p>Yana S. Yudina, 5th-year Student, Dental Institute</p><p>89 Chapaevskaya Str., Samara, 443099</p></bio><email xlink:type="simple">yanozkay@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>04</day><month>05</month><year>2025</year></pub-date><volume>25</volume><issue>1</issue><fpage>73</fpage><lpage>83</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Постников М.А., Винник А.В., Костионова-Овод И.А., Апполонова Ю.Ю., Юдина Я.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Постников М.А., Винник А.В., Костионова-Овод И.А., Апполонова Ю.Ю., Юдина Я.С.</copyright-holder><copyright-holder xml:lang="en">Postnikov M.A., Vinnik A.V., Kostionova-Ovod I.A., Appolonova Y.Y., Yudina Y.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.detstom.ru/jour/article/view/797">https://www.detstom.ru/jour/article/view/797</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Концепция бактериотерапии в данный момент является развивающейся областью медицины, в том числе и стоматологии. Микробиом играет важную роль в ключе общего и местного иммунитета, так как в полости рта обитают около 300 видов микроорганизмов, часть которых считается условно-патогенной, может быть источником различных заболевания слизистой оболочки. В отечественной и зарубежной литературе описано большое количество случаев применения пробиотиков в профилактике и лечение широкого спектра заболеваний ЖКТ. В настоящее время активно изучается роль пробиотиков в поддержании общего гомеостаза, в частности гомеостаза полости рта. Становится актуальным исследование эффективности пробиотиков в качестве профилактических препаратов заболеваний полости рта.</p></sec><sec><title>Цель</title><p>Цель. Проанализировать данные отечественной и зарубежной литературы за последние 10 лет и представить описание применения пробиотиков в стоматологии.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Для изучения вопроса о применении пробиотиков в стоматологии были подробно проанализированы данные 80 публикаций (статьи, серии случаев, обзоры литературы) за последние 10 лет. Для поиска данных использованы базы научной литературы Pubmed, eLibrary, Scopus. Были рассмотрены вопросы эффективности применения пробиотиков в стоматологической практике, механизм их действия, виды микроорганизмов, входящих в состав пробиотических препаратов, требования, предъявляемые к пробиотикам, их влияние на иммунитет, а также эффективность использования пробиотиков в качестве вспомогательного или профилактического терапевтического средства.</p></sec><sec><title>Результаты</title><p>Результаты. В настоящее время все большую популярность получает применение пробиотиков для профилактики и комплексного лечения заболеваний полости рта. Пробиотики обеспечивают защиту организма от проникновения болезнетворных бактерий, бактериальных токсинов и токсических продуктов различного происхождения. Их полезное действие определяется прежде всего их способностью подавлять патогенные микроорганизмы благодаря образованию антимикробных веществ, а также иммуномодулирующего действия на организм человека. Также, за счет улучшения сигнальных путей местного и системного иммуновоспалительного ответа организма, пробиотики улучшают барьерную функцию эпителия.</p></sec><sec><title>Заключение</title><p>Заключение. Применение пробиотиков или синбиотиков в профилактических целях способствует адекватному функционированию иммунной системы, снижению риска возникновения кариеса, галитоза, обострений заболеваний пародонта. Исследования последних лет доказывают, что данные препараты способствуют укреплению здоровья полости рта.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. The concept of probiotic therapy is currently an emerging field in medicine, including dentistry. The oral microbiome plays a critical role in both systemic and local immune responses, as approximately 300 microbial species inhabit the oral environment, some of which are considered opportunistic pathogens and may contribute to various mucosal diseases. Numerous reports in both domestic and international literature have described the use of probiotics for the prevention and treatment of a wide range of gastrointestinal disorders. Increasing attention is now being paid to the role of probiotics in maintaining overall physiological balance, particularly within the oral environment. Accordingly, evaluating the effectiveness of probiotics as preventive agents in the management of oral diseases is becoming increasingly relevant.</p></sec><sec><title>Objective</title><p>Objective. To analyze data from Russian and international literature published over the past decade and to provide an overview of the application of probiotics in dentistry.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A total of 80 publications (including original research articles, case series, and literature reviews) from the past 10 years were thoroughly analyzed to explore the application of probiotics in dental practice. The literature search was conducted using the PubMed, eLibrary, and Scopus databases. Key aspects under review included the clinical efficacy of probiotics in dentistry, mechanisms of action, microbial strains used in probiotic formulations, criteria for probiotic agents, their effects on immune function, and their role as adjunctive or preventive therapeutic modalities.</p></sec><sec><title>Results</title><p>Results. The application of probiotics for both the prevention and comprehensive management of oral diseases is gaining increasing recognition. Probiotics contribute to host protection by inhibiting pathogenic bacteria, neutralizing bacterial toxins, and reducing the impact of various harmful metabolites. Their beneficial effects are largely attributed to the production of antimicrobial compounds and their immunomodulatory activity. Additionally, probiotics enhance epithelial barrier function by modulating local and systemic immune-inflammatory signaling pathways.</p></sec><sec><title>Conclusion</title><p>Conclusion. The use of probiotics or synbiotics as preventive agents supports the proper functioning of the immune system and reduces the risk of dental caries, halitosis, and exacerbations of periodontal diseases. Recent evidence confirms that these interventions contribute meaningfully to improved oral health outcomes.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>пробиотики</kwd><kwd>пребиотики</kwd><kwd>заболевания полости рта</kwd><kwd>кариес</kwd><kwd>галитоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>probiotics</kwd><kwd>prebiotics</kwd><kwd>oral diseases</kwd><kwd>dental caries</kwd><kwd>halitosis</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы заявляют об отсутствии внешнего финансирования при проведении исследования.</funding-statement><funding-statement xml:lang="en">The authors declare that there was no external funding for the study.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Anusha RL, Umar D, Basheer B, Baroudi K. The magic of magic bugs in oral cavity: Probiotics. 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