<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detstom</journal-id><journal-title-group><journal-title xml:lang="ru">Стоматология детского возраста и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric dentistry and dental prophylaxis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3031</issn><issn pub-type="epub">1726-7218</issn><publisher><publisher-name>RPA</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3031-2022-22-2-143-151</article-id><article-id custom-type="elpub" pub-id-type="custom">detstom-496</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Роль вируса простого герпеса первого типа в заболеваниях полости рта у детей</article-title><trans-title-group xml:lang="en"><trans-title>The role of Herpes Simplex Virus type 1 in oral diseases in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2477-3676</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивановский</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanovskii</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Ивановский Владислав Андреевич, аспирант кафедры пропедевтики стоматологических заболеваний </p><p> Санкт-Петербург</p></bio><bio xml:lang="en"><p> Vladislav A. Ivanovskii, DMD, PhD student, Department of Introduction to Dental Diseases</p><p>Saint Petersburg </p></bio><email xlink:type="simple">ivanovskiy.1995@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2543-6137</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антонова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Antonova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Антонова Ирина Николаевна, доктор медицинских наук, профессор, директор Научно-исследовательского института стоматологии и челюстно-лицевой хирургии, заведующая кафедрой пропедевтики стоматологических заболеваний</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p> Irina N. Antonova, DMD, PhD, DSc, Professor, Director of the Research Institute of Dentistry and Maxillofacial Surgery, Head of the Department of Introduction to Dental Diseases</p><p>Saint Petersburg </p></bio><email xlink:type="simple">irina.antonova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8219-8169</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молокова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Molokova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Молокова Виктория Алексеевна, ординатор кафедры пропедевтики стоматологических заболеваний, врач-стоматолог общей практики Научно-исследовательского института стоматологии и челюстно-лицевой хирургии </p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p> Viktoriia A.Molokova, DMD, Resident, Department of Introduction to Dental Diseases, General Dentist, Research Institute of Dentistry and Maxillofacial surgery</p><p>Saint Petersburg </p></bio><email xlink:type="simple">molokona1997@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov First Saint Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>22</day><month>06</month><year>2022</year></pub-date><volume>22</volume><issue>2</issue><fpage>143</fpage><lpage>151</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ивановский В.А., Антонова И.Н., Молокова В.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ивановский В.А., Антонова И.Н., Молокова В.А.</copyright-holder><copyright-holder xml:lang="en">Ivanovskii V.A., Antonova I.N., Molokova V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.detstom.ru/jour/article/view/496">https://www.detstom.ru/jour/article/view/496</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Инфекции, вызванные вирусом герпеса, относятся к числу наиболее распространенных и плохо контролируемых вирусных заболеваний. В стоматологической практике часто возникают трудности с верификацией и лечением герпетических поражений полости рта.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Представить результаты изучения зарубежных публикаций, посвященных роли вируса простого герпеса первого типа в развитии заболеваний полости рта у детей.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Материал исследования основан на данных зарубежных научных статей за 2018-2022 гг. по проблеме заболеваний полости рта, вызываемых вирусом простого герпеса первого типа. Поиск источников выполнялся с помощью библиографических баз данных PubMed и Google Scholar.</p></sec><sec><title>Результаты</title><p>Результаты. В статье представлены последние данные о распространенности, клинических особенностях и методах диагностики герпетических поражений полости рта у детей. Основными клиническими формами герпетической инфекции, диагностируемыми в стоматологической клинической практике, являются острый герпетический гингивостоматит, хронический рецидивирующий герпетический гингивостоматит и хронический рецидивирующий губной герпес. Острый герпетический гингивостоматит широко распространен у детей в возрасте от 6 месяцев до 5 лет и встречается у новорожденных от 2 до 43 дней после рождения. Успехи современной вирусологии позволяют улучшить диагностику и лечение герпетических поражений полости рта.</p></sec><sec><title>Заключение</title><p>Заключение. Острый герпетический гингивостоматит, являясь острым инфекционным заболеванием, требует совместного внимание врача общей практики и стоматолога для обеспечения комплексного лечения.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Herpes virus infections are the most common and poorly controllable viral infections. There are many difficulties in herpetic lesion verification and treatment in dental practice.</p></sec><sec><title>Purpose</title><p>Purpose. The study aimed to present the results of a foreign publication investigation on the role of herpes simplex virus type 1 in the development of oral diseases in children.</p></sec><sec><title>Material and methods</title><p>Material and methods. Foreign scientific articles about the oral HSV-1 infections published from 2018 to 2022 formed the basis for the study. The study searched the publications on PubMed and Google Scholar bases.</p></sec><sec><title>Results</title><p>Results. The article presents the newest data on the prevalence, clinical characteristics and diagnosis of oral HSV infection in children. Primary herpetic gingivostomatitis (PHGS), chronic recurrent herpetic gingivostomatitis, chronic recurrent herpes labialis are the main clinical presentations of herpes infection diagnosed in a dental practice. Primary herpetic gingivostomatitis is very common in children aged six months to fve years and occurs in newborns from 2 to 43 days of life. Modern virology success can improve diagnosis and treatment of oral herpetic lesions.</p></sec><sec><title>Conclusion</title><p>Conclusion. Primary herpetic gingivostomatitis is an acute infectious disease that requires the joint attention of a general practitioner and a dentist to ensure comprehensive treatment.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>вирус простого герпеса</kwd><kwd>полость рта</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Herpes Simplex Virus</kwd><kwd>oral cavity</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Clarkson E, Mashkoor F, Abdulateef S. Oral Viral Infections: Diagnosis and Management. Dent Clin North Am. 2017;61(2):351-363. doi: 10.1016/j.cden.2016.12.005.</mixed-citation><mixed-citation xml:lang="en">Clarkson E, Mashkoor F, Abdulateef S. Oral Viral Infections: Diagnosis and Management. Dent Clin North Am. 2017;61(2):351-363. doi: 10.1016/j.cden.2016.12.005.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Atyeo N, Rodriguez MD, Papp B, Toth Z. Clinical Manifestations and Epigenetic Regulation of Oral Herpesvirus Infections. Viruses. 2021;13(4):681. doi: 10.3390/v13040681.</mixed-citation><mixed-citation xml:lang="en">Atyeo N, Rodriguez MD, Papp B, Toth Z. Clinical Manifestations and Epigenetic Regulation of Oral Herpesvirus Infections. Viruses. 2021;13(4):681. doi: 10.3390/v13040681.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Boitsaniuk SI, Levkiv MО, Fedoniuk LY, Kuzniak NB, Bambuliak AV. Acute herpetic stomatitis: clinical manifestations, diagnostics and treatment strategies. Wiad Lek. 2022;75(1pt2):318-323 doi: 10.36740/WLek202201229.</mixed-citation><mixed-citation xml:lang="en">Boitsaniuk SI, Levkiv MО, Fedoniuk LY, Kuzniak NB, Bambuliak AV. Acute herpetic stomatitis: clinical manifestations, diagnostics and treatment strategies. Wiad Lek. 2022;75(1pt2):318-323 doi: 10.36740/WLek202201229.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Santosh ABR, Muddana K. Viral infections of oral cavity. J Family Med Prim Care. 2020;9(1):36-42. doi: 10.4103/jfmpc.jfmpc_807_19.</mixed-citation><mixed-citation xml:lang="en">Santosh ABR, Muddana K. Viral infections of oral cavity. J Family Med Prim Care. 2020;9(1):36-42. doi: 10.4103/jfmpc.jfmpc_807_19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Реук СЭ, Терехина НА. Разработка способа оценки эффективности лечения детей больных герпетическим стоматитом. Клиническая лабораторная диагностика. 2020;65(5):269-274 doi: 10.18821/0869-2084-2020-65-5-269-274</mixed-citation><mixed-citation xml:lang="en">Reuk SE, Terekhina NA. Development of a method for evaluating the effectiveness of treatment of children with herpetic stomatitis. Klin Lab Diagn. 2020;65(5):269-274 (In Russ.). doi: 10.18821/0869-2084-2020-65-5-269-274.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Andrews RJ, O’Leary CA, Moss WN. A survey of RNA secondary structural propensity encoded within human herpesvirus genomes: global comparisons and local motifs. Peer J. 2020;8:9882. doi: 10.7717/peerj.9882.</mixed-citation><mixed-citation xml:lang="en">Andrews RJ, O’Leary CA, Moss WN. A survey of RNA secondary structural propensity encoded within human herpesvirus genomes: global comparisons and local motifs. Peer J. 2020;8:9882. doi: 10.7717/peerj.9882.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Madavaraju K, Koganti R, Volety I, Yadavalli T, Shukla D. Herpes Simplex Virus Cell Entry Mechanisms: An Update. Front Cell Infect Microbiol. 2021;10:617578. doi: 10.3389/fcimb.2020.617578.</mixed-citation><mixed-citation xml:lang="en">Madavaraju K, Koganti R, Volety I, Yadavalli T, Shukla D. Herpes Simplex Virus Cell Entry Mechanisms: An Update. Front Cell Infect Microbiol. 2021;10:617578. doi: 10.3389/fcimb.2020.617578.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Whitley R, Baines J. Clinical management of herpes simplex virus infections: past, present, and future. F1000Res. 2018;7:F1000 Faculty Rev-1726. doi: 10.12688/f1000research</mixed-citation><mixed-citation xml:lang="en">Whitley R, Baines J. Clinical management of herpes simplex virus infections: past, present, and future. F1000Res. 2018;7:F1000 Faculty Rev-1726. doi: 10.12688/f1000research</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen JI. Herpesvirus latency. J. Clin. Investig. 2020;130:3361-3369. doi: 10.1172/JCI136225.</mixed-citation><mixed-citation xml:lang="en">Cohen JI. Herpesvirus latency. J. Clin. Investig. 2020;130:3361-3369. doi: 10.1172/JCI136225.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Suzich JB, Cliffe AR. Strength in diversity: Understanding the pathways to herpes simplex virus reactivation. Virology. 2018;522:81-91 doi: 10.1016/j.virol.2018.07.011.</mixed-citation><mixed-citation xml:lang="en">Suzich JB, Cliffe AR. Strength in diversity: Understanding the pathways to herpes simplex virus reactivation. Virology. 2018;522:81-91 doi: 10.1016/j.virol.2018.07.011.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Dai X, Zhou ZH. Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes. Science. 2018;360:7298. doi: 10.1126/science.aao7298.</mixed-citation><mixed-citation xml:lang="en">Dai X, Zhou ZH. Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes. Science. 2018;360:7298. doi: 10.1126/science.aao7298.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">James C, Harfouche M, Welton NJ, Turner KM, Abu-Raddad LJ, Gottlieb SL, et al. Herpes simplex virus: global infection prevalence and incidence estimates, 2016. Bull World Health Organ. 2020;98(5):315-329. doi: 10.2471/BLT.19.237149.</mixed-citation><mixed-citation xml:lang="en">James C, Harfouche M, Welton NJ, Turner KM, AbuRaddad LJ, Gottlieb SL, et al. Herpes simplex virus: global infection prevalence and incidence estimates, 2016. Bull World Health Organ. 2020;98(5):315-329. doi: 10.2471/BLT.19.237149.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Lan K, Luo MH. Herpesviruses: epidemiology, pathogenesis, and interventions. Virol Sin. 2017;32(5):347-348. doi: 10.1007/s12250-017-4108-2</mixed-citation><mixed-citation xml:lang="en">Lan K, Luo MH. Herpesviruses: epidemiology, pathogenesis, and interventions. Virol Sin. 2017;32(5):347-348. doi: 10.1007/s12250-017-4108-2</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang SY. Herpes simplex virus encephalitis of childhood: inborn errors of central nervous system cellintrinsic immunity. Hum Genet. 2020;139(6-7):911-918. doi: 10.1007/s00439-020-02127-5.</mixed-citation><mixed-citation xml:lang="en">Zhang SY. Herpes simplex virus encephalitis of childhood: inborn errors of central nervous system cellintrinsic immunity. Hum Genet. 2020;139(6-7):911-918. doi: 10.1007/s00439-020-02127-5.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Crimi S, Fiorillo L, Bianchi A, D'Amico C, Amoroso G, Gorassini F, et al. Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data. Viruses. 2019;11(5):463. doi: 10.3390/v11050463.</mixed-citation><mixed-citation xml:lang="en">Crimi S, Fiorillo L, Bianchi A, D'Amico C, Amoroso G, Gorassini F, et al. Herpes Virus, Oral Clinical Signs and QoL: Systematic Review of Recent Data. Viruses. 2019;11(5):463. doi: 10.3390/v11050463.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Autore G, Bernardi L, Perrone S, Esposito S. Update on Viral Infections Involving the Central Nervous System in Pediatric Patients. Children (Basel). 2021;8(9):782. doi: 10.3390/children8090782.</mixed-citation><mixed-citation xml:lang="en">Autore G, Bernardi L, Perrone S, Esposito S. Update on Viral Infections Involving the Central Nervous System in Pediatric Patients. Children (Basel). 2021;8(9):782. doi:  10.3390/children8090782.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yang H, Yang X, Wang Y, Zheng X, Zhang Y, Shao Y. Comparative analysis of the tear protein profile in herpes simplex virus type 1 epithelial keratitis. BMC Ophthalmol. 2020;20(1):355. doi: 10.1186/s12886-020-01626-3.</mixed-citation><mixed-citation xml:lang="en">Yang H, Yang X, Wang Y, Zheng X, Zhang Y, Shao Y. Comparative analysis of the tear protein profile in herpes simplex virus type 1 epithelial keratitis. BMC Ophthalmol. 2020;20(1):355. doi: 10.1186/s12886-020-01626-3.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Guda SJM, Sontam B, Bagga B, Ranjith K, Sharma S., Joseph Evaluation of multiplex real-time polymerase chain reaction for the detection of herpes simplex virus-1 and 2 and varicella-zoster virus in corneal cells from normal subjects and patients with keratitis in India J. Indian J Ophthalmol. 2019;67(7):1040-1046. doi: 10.4103/ijo.IJO_1700_18.</mixed-citation><mixed-citation xml:lang="en">Guda SJM, Sontam B, Bagga B, Ranjith K, Sharma S., Joseph Evaluation of multiplex real-time polymerase chain reaction for the detection of herpes simplex virus-1 and 2 and varicella-zoster virus in corneal cells from normal subjects and patients with keratitis in India J. Indian J Ophthalmol. 2019;67(7):1040-1046. doi: 10.4103/ijo.IJO_1700_18.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Karimi-Boroujeni M, Zahedi-Amiri A, Coombs KM. Embryonic Origins of Virus-Induced Hearing Loss: Overview of Molecular Etiology. Viruses. 2021;13(1):71. doi: 10.3390/v13010071.</mixed-citation><mixed-citation xml:lang="en">Karimi-Boroujeni M, Zahedi-Amiri A, Coombs KM. Embryonic Origins of Virus-Induced Hearing Loss: Overview of Molecular Etiology. Viruses. 2021;13(1):71. doi: 10.3390/v13010071.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Smith LM, Ismail OM, Mojica G. Ocular Manifestations of Herpes Simplex Virus in the Pediatric Population. Int Ophthalmol Clin. 2022;62(1):73-81.doi: 10.1097/IIO.0000000000000394.</mixed-citation><mixed-citation xml:lang="en">Smith LM, Ismail OM, Mojica G. Ocular Manifestations of Herpes Simplex Virus in the Pediatric Population. Int Ophthalmol Clin. 2022;62(1):73-81.doi: 10.1097/IIO.0000000000000394.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lerch M, Mainetti C, Beretta-Piccoli B, Harr T. Current perspectives on erythema multiforme. Clin. Rev. Allergy Immunol. 2018;54:177-184. doi: 10.1007/s12016-017-8667-7.</mixed-citation><mixed-citation xml:lang="en">Lerch M, Mainetti C, Beretta-Piccoli B, Harr T. Current perspectives on erythema multiforme. Clin. Rev. Allergy Immunol. 2018;54:177-184. doi: 10.1007/s12016-017-8667-7.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chang WJ, Wang HY, Huang YC, Lin CY, Leu SW, Hsieh MJ, et al. Outcomes of Herpes Simplex Virus Pneumonitis in Critically Ill Patients. Viruses. 2022;14(2):205. doi: 10.3390/v14020205.</mixed-citation><mixed-citation xml:lang="en">Chang WJ, Wang HY, Huang YC, Lin CY, Leu SW, Hsieh MJ, et al. Outcomes of Herpes Simplex Virus Pneumonitis in Critically Ill Patients. Viruses. 2022;14(2):205. doi: 10.3390/v14020205.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Itzhaki RF. Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease. Front Aging Neurosci. 2018;10:324. doi: 10.3389/fnagi.2018.00324.</mixed-citation><mixed-citation xml:lang="en">Itzhaki RF. Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer's Disease. Front Aging Neurosci. 2018;10:324. doi: 10.3389/fnagi.2018.00324.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Doll JR, Hoebe K, Thompson RL, Sawtell NM. Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction. PLoS pathogen. 2020;16(3):e1008296. doi: 10.1371/journal.ppat.1008296.</mixed-citation><mixed-citation xml:lang="en">Doll JR, Hoebe K, Thompson RL, Sawtell NM. Resolution of herpes simplex virus reactivation in vivo results in neuronal destruction. PLoS pathogen. 2020;16(3):e1008296. doi: 10.1371/journal.ppat.1008296.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Petti S, Lodi G. The controversial natural history of oral herpes simplex virus type 1 infection. Oral Dis. 2019;25:1850-1865. doi: 10.1111/odi.13234.</mixed-citation><mixed-citation xml:lang="en">Petti S, Lodi G. The controversial natural history of oral herpes simplex virus type 1 infection. Oral Dis. 2019;25:1850-1865. doi: 10.1111/odi.13234.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Dhull D, Sharma V, Sharma Y, Kaushik S. Applicability of molecular assays for detection and typing of herpes simplex viruses in encephalitis cases. Virusdisease. 2019;30(4):504-510. doi: 10.1007/s13337-019-00558-x.</mixed-citation><mixed-citation xml:lang="en">Dhull D, Sharma V, Sharma Y, Kaushik S. Applicability of molecular assays for detection and typing of herpes simplex viruses in encephalitis cases. Virusdisease. 2019;30(4):504-510. doi: 10.1007/s13337-019-00558-x.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Yan C, Luo Z, Li W, Li X, Dallmann R, Kurihara H, et al. Disturbed Yin-Yang balance: Stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1. Acta Pharm. Sin. B. 2020;10:383-398. doi: 10.1016/j.apsb.2019.06.005.</mixed-citation><mixed-citation xml:lang="en">Yan C, Luo Z, Li W, Li X, Dallmann R, Kurihara H, et al. Disturbed Yin-Yang balance: Stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1. Acta Pharm. Sin. B. 2020;10:383-398. doi: 10.1016/j.apsb.2019.06.005.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Ayoub HH, Chemaitelly H, Abu-Raddad LJ. Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: Model-based predictions. BMC Med. 2019;17(1):57. doi: 10.1186/s12916-019-1285-x.</mixed-citation><mixed-citation xml:lang="en">Ayoub HH, Chemaitelly H, Abu-Raddad LJ. Characterizing the transitioning epidemiology of herpes simplex virus type 1 in the USA: Model-based predictions. BMC Med. 2019;17(1):57. doi: 10.1186/s12916-019-1285-x.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ashwini Rani SR, Suragimath G, Rajmane V, Rajmane Y. Prevalence of recurrent herpes labialis in Western Maharashtra. J Oral Maxillofac Pathol. 2021;25(1):51-54. doi: 10.4103/jomfp.JOMFP_204_20.</mixed-citation><mixed-citation xml:lang="en">Ashwini Rani SR, Suragimath G, Rajmane V, Rajmane Y. Prevalence of recurrent herpes labialis in Western Maharashtra. J Oral Maxillofac Pathol. 2021;25(1):51-54. doi: 10.4103/jomfp.JOMFP_204_20.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ahluwalia J, Han A, Kusari A, Eichenfield LF. Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications. Pediatr Dermatol. 2019;36(6):808-814. doi: 10.1111/pde.13978.</mixed-citation><mixed-citation xml:lang="en">Ahluwalia J, Han A, Kusari A, Eichenfield LF. Recurrent herpes labialis in the pediatric population: Prevalence, therapeutic studies, and associated complications. Pediatr Dermatol. 2019;36(6):808-814. doi: 10.1111/pde.13978.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Heliotis I, Whatling R, Desai S, Visavadia M. Primary herpetic gingivostomatitis in children. BMJ. 2021;375:e065540. doi: 10.1136/bmj-2021-065540.</mixed-citation><mixed-citation xml:lang="en">Heliotis I, Whatling R, Desai S, Visavadia M. Primary herpetic gingivostomatitis in children. BMJ. 2021;375:e065540. doi: 10.1136/bmj-2021-065540.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Aslanova M, Ali R., Zito PM. Herpetic Gingivostomatitis. 2021. In: StatPearls [Internet]. Treasure Island (FL): StatPearls. Режим доступа / Available from: https://www.ncbi.nlm.nih.gov/books/NBK526068/</mixed-citation><mixed-citation xml:lang="en">Aslanova M, Ali R., Zito PM. Herpetic Gingivostomatitis. 2021. In: StatPearls [Internet]. Treasure Island (FL): StatPearls. Режим доступа / Available from: https://www.ncbi.nlm.nih.gov/books/NBK526068/</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hong CHL, Dean DR, Hull K, Hu SJ, Sim YF, Nadeau C, et al. World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review. Oral Dis. 2019;25(1):193-203. doi: 10.1111/odi.13112.</mixed-citation><mixed-citation xml:lang="en">Hong CHL, Dean DR, Hull K, Hu SJ, Sim YF, Nadeau C, et al. World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review. Oral Dis. 2019;25(1):193-203. doi: 10.1111/odi.13112.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Zou J. Clinical diagnosis and treatment of herpes simplex virus infection on oral mucosa in children. Zhonghua Kou Qiang Yi Xue Za Zhi. 2019;54(4):286-288. doi: 10.3760/cma.j.issn.1002-0098.2019.04.016.</mixed-citation><mixed-citation xml:lang="en">Zou J. Clinical diagnosis and treatment of herpes simplex virus infection on oral mucosa in children. Zhonghua Kou Qiang Yi Xue Za Zhi. 2019;54(4):286-288. doi: 10.3760/cma.j.issn.1002-0098.2019.04.016.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">La Selva A, Negreiros RM, Bezerra DT, Rosa EP, Pavesi VCS, Navarro RS, et al. Treatment of herpes labialis byphotodynamic therapy: Study protocol clinical trial (SPIRITcompliant). Medicine (Baltimore). 2020;99(12):e19500. doi: 10.1097/MD.0000000000019500.</mixed-citation><mixed-citation xml:lang="en">La Selva A, Negreiros RM, Bezerra DT, Rosa EP, Pavesi VCS, Navarro RS, et al. Treatment of herpes labialis byphotodynamic therapy: Study protocol clinical trial (SPIRITcompliant). Medicine (Baltimore). 2020;99(12):e19500. doi: 10.1097/MD.0000000000019500.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Huang CW, Hsieh CH, Lin MR, Huang YC. Clinical features of gingivostomatitis due to primary infection of herpes simplex virus in children. BMC Infect Dis. 2020;20(1):782. doi: 10.1186/s12879-020-05509-2.</mixed-citation><mixed-citation xml:lang="en">Huang CW, Hsieh CH, Lin MR, Huang YC. Clinical features of gingivostomatitis due to primary infection of herpes simplex virus in children. BMC Infect Dis. 2020;20(1):782. doi: 10.1186/s12879-020-05509-2.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Bardellini E, Amadori F, Veneri F, Conti G, Paderno A, Majorana A. Adolescents and primary herpetic gingivostomatitis: an Italian overview. Irish Journal of Medical Science. 2021;1-5. Online ahead of print. doi: 10.1007/s11845-021-02621-3.</mixed-citation><mixed-citation xml:lang="en">Bardellini E, Amadori F, Veneri F, Conti G, Paderno A, Majorana A. Adolescents and primary herpetic gingivostomatitis: an Italian overview. Irish Journal of Medical Science. 2021;1-5. Online ahead of print.  doi: 10.1007/s11845-021-02621-3.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Abdel-Naby Awad OG, Hamad AH. Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial. Am J Otolaryngol. 2018;39(6):759-763. doi: 10.1016/j.amjoto.2018.09.007.</mixed-citation><mixed-citation xml:lang="en">Abdel-Naby Awad OG, Hamad AH. Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial. Am J Otolaryngol. 2018;39(6):759-763. doi: 10.1016/j.amjoto.2018.09.007.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Chiang YT, Hwang MJ, Lee YP, Chiang CP. Differential diagnosis between herpetic gingivostomatitis and herpetiform aphthous ulcerations. J Dent Sci. 2020;15(3):386-387. doi: 10.1016/j.jds.2020.06.001.</mixed-citation><mixed-citation xml:lang="en">Chiang YT, Hwang MJ, Lee YP, Chiang CP. Differential diagnosis between herpetic gingivostomatitis and herpetiform aphthous ulcerations. J Dent Sci. 2020;15(3):386-387. doi: 10.1016/j.jds.2020.06.001.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Aloyouny AY, Albagieh HN, Al-Serwi RH. Oral and perioral herpes simplex virus infection type I in a fivemonth-old infant: A case report. World J Clin Cases. 2021;9(3):685-689. doi: 10.12998/wjcc.v9.i3.685.</mixed-citation><mixed-citation xml:lang="en">Aloyouny AY, Albagieh HN, Al-Serwi RH. Oral and perioral herpes simplex virus infection type I in a fivemonth-old infant: A case report. World J Clin Cases. 2021;9(3):685-689. doi: 10.12998/wjcc.v9.i3.685.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Mahant S, Hall M, Schondelmeyer AC, Berry JG, Kimberlin DW, Shah SS, Pediatric Research in Inpatient Settings Network and the Collaborative Antiviral Study Group. Neonatal Herpes Simplex Virus Infection Among Medicaid-Enrolled Children: 2009-2015. Pediatrics. 2019;143(4):e20183233. doi: 10.1542/peds.2018-3233.</mixed-citation><mixed-citation xml:lang="en">Mahant S, Hall M, Schondelmeyer AC, Berry JG, Kimberlin DW, Shah SS, Pediatric Research in Inpatient Settings Network and the Collaborative Antiviral Study Group. Neonatal Herpes Simplex Virus Infection Among Medicaid-Enrolled Children: 2009-2015. Pediatrics. 2019;143(4):e20183233. doi: 10.1542/peds.2018-3233.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandes ND, Arya K, Ward R. Congenital Herpes Simplex. 2021 Dec 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Режим доступа / Available from: https://www.statpearls.com/ArticleLibrary/viewarticle/19855</mixed-citation><mixed-citation xml:lang="en">Fernandes ND, Arya K, Ward R. Congenital Herpes Simplex. 2021 Dec 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Режим доступа / Available from: https://www.statpearls.com/ArticleLibrary/viewarticle/19855</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Samies NL, James SH. Prevention and treatment of neonatal herpes simplex virus infection. Antiviral Res. 2020;176:104721. doi: 10.1016/j.antiviral.2020.104721.</mixed-citation><mixed-citation xml:lang="en">Samies NL, James SH. Prevention and treatment of neonatal herpes simplex virus infection. Antiviral Res. 2020;176:104721. doi: 10.1016/j.antiviral.2020.104721.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Renk H, Hartleif S, Hamprecht K. Disseminated neonatal herpes simplex virus infection: postnatal acquisition and familial spread during migration to Germany. Travel Med Infect Dis. 2019;29:75-77. doi: 10.1016/j.tmaid.2019.01.005.</mixed-citation><mixed-citation xml:lang="en">Renk H, Hartleif S, Hamprecht K. Disseminated neonatal herpes simplex virus infection: postnatal acquisition and familial spread during migration to Germany. Travel Med Infect Dis. 2019;29:75-77. doi: 10.1016/j.tmaid.2019.01.005.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kidszun A, Bruns A, Schreiner D, Tippmann S, Winter J, Pokora RM, et al. Characteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study. Arch Dis Child Fetal Neonatal Ed. 2022;107(2):188-192. doi: 10.1136/archdischild-2021-321940.</mixed-citation><mixed-citation xml:lang="en">Kidszun A, Bruns A, Schreiner D, Tippmann S, Winter J, Pokora RM, et al. Characteristics of neonatal herpes simplex virus infections in Germany: results of a 2-year prospective nationwide surveillance study. Arch Dis Child Fetal Neonatal Ed. 2022;107(2):188-192. doi: 10.1136/archdischild-2021-321940.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Neuberger I, Garcia J, Meyers ML, Feygin T, Bulas DI, Mirsky DM. Imaging of congenital central nervous system infections. Pediatr Radiol. 2018;48(4):513-523. doi: 10.1007/s00247-018-4092-1.</mixed-citation><mixed-citation xml:lang="en">Neuberger I, Garcia J, Meyers ML, Feygin T, Bulas DI, Mirsky DM. Imaging of congenital central nervous system infections. Pediatr Radiol. 2018;48(4):513-523. doi: 10.1007/s00247-018-4092-1.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Drumm CM, Caufield MC, DeKlotz CM, Pasieka HB, Abubakar KM. Intrauterine Herpes Simplex Virus Infection Presenting as a Zosteriform Eruption in a Newborn. AJP Rep. 2018;8(1):33-36. doi: 10.1055/s-0038-1635100.</mixed-citation><mixed-citation xml:lang="en">Drumm CM, Caufield MC, DeKlotz CM, Pasieka HB, Abubakar KM. Intrauterine Herpes Simplex Virus Infection Presenting as a Zosteriform Eruption in a Newborn. AJP Rep. 2018;8(1):33-36. doi: 10.1055/s-0038-1635100.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Xu X, Zhang Y, Li Q. Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development. Rev. Med. Virol. 2019;29(4):2054. doi: 10.1002/rmv.2054.</mixed-citation><mixed-citation xml:lang="en">Xu X, Zhang Y, Li Q. Characteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development. Rev. Med. Virol. 2019;29(4):2054. doi: 10.1002/rmv.2054.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Nath P, Kabir MA, Doust SK, Ray A. Diagnosis of Herpes Simplex Virus: Laboratory and Point-of-Care Techniques. Infect Dis Rep. 2021;13(2):518-539. doi: 10.3390/idr13020049.</mixed-citation><mixed-citation xml:lang="en">Nath P, Kabir MA, Doust SK, Ray A. Diagnosis of Herpes Simplex Virus: Laboratory and Point-of-Care Techniques. Infect Dis Rep. 2021;13(2):518-539. doi: 10.3390/idr13020049.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Mortazavi H, Safi Y, Baharvand M, Rahmani S. Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree. Int J Dent. 2016;2016:7278925. doi: 10.1155/2016/7278925</mixed-citation><mixed-citation xml:lang="en">Mortazavi H, Safi Y, Baharvand M, Rahmani S. Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree. Int J Dent. 2016;2016:7278925. doi: 10.1155/2016/7278925</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Arshad Z, Alturkistani A, Brindley D, Lam C, Foley K, Meinert E. Tools for the Diagnosis of Herpes Simplex Virus 1/2: Systematic Review of Studies Published Between 2012 and 2018. JMIR Public Health Surveill. 2019;5(2):14216. doi: 10.2196/14216.</mixed-citation><mixed-citation xml:lang="en">Arshad Z, Alturkistani A, Brindley D, Lam C, Foley K, Meinert E. Tools for the Diagnosis of Herpes Simplex Virus 1/2: Systematic Review of Studies Published Between 2012 and 2018. JMIR Public Health Surveill. 2019;5(2):14216. doi: 10.2196/14216.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Thomasini RL, Pereira FSM. Impact of different types of herpesviral infections in the oral cavity. World J Stomatol. 2016;5(2):22-27. doi: 10.5321/wjs.v5.i2.22.</mixed-citation><mixed-citation xml:lang="en">Thomasini RL, Pereira FSM. Impact of different types of herpesviral infections in the oral cavity. World J Stomatol. 2016;5(2):22-27. doi: 10.5321/wjs.v5.i2.22.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Patwardhan V, Bhalla P, Rawat D, Garg VK, Sardana K., Sethi S. A Comparative Analysis of Polymerase Chain Reaction and Direct Fluorescent Antibody Test for Diagnosis of Genital Herpes. J Lab Physicians. 2017;9(1):53-56. doi: 10.4103/0974-2727.187929.</mixed-citation><mixed-citation xml:lang="en">Patwardhan V, Bhalla P, Rawat D, Garg VK, Sardana K., Sethi S. A Comparative Analysis of Polymerase Chain Reaction and Direct Fluorescent Antibody Test for Diagnosis of Genital Herpes. J Lab Physicians. 2017;9(1):53-56. doi: 10.4103/0974-2727.187929.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Garg N, Boyle D, Randall A, Teng A, Pablo J, Liang X, et al. Rapid immunodiagnostics of multiple viral infections in an acoustic microstreaming device with serum and saliva samples. Lab Chip. 2019;19(9):1524-1533. doi: 10.1039/c8lc01303a.</mixed-citation><mixed-citation xml:lang="en">Garg N, Boyle D, Randall A, Teng A, Pablo J, Liang X, et al. Rapid immunodiagnostics of multiple viral infections in an acoustic microstreaming device with serum and saliva samples. Lab Chip. 2019;19(9):1524-1533. doi: 10.1039/c8lc01303a.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Zuo Y, Whitbeck JC, Haila GJ, Hakim AA, Rothlauf PW, Eisenberg RJ. Saliva enhances infection of gingival fbroblasts by herpes simplex virus 1. PLoS ONE. 2019;14(10):0223299. doi: 10.1371/journal.pone.0223299</mixed-citation><mixed-citation xml:lang="en">Zuo Y, Whitbeck JC, Haila GJ, Hakim AA, Rothlauf PW, Eisenberg RJ. Saliva enhances infection of gingival fbroblasts by herpes simplex virus 1. PLoS ONE. 2019;14(10):0223299. doi: 10.1371/journal.pone.0223299</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
