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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detstom</journal-id><journal-title-group><journal-title xml:lang="ru">Стоматология детского возраста и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric dentistry and dental prophylaxis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3031</issn><issn pub-type="epub">1726-7218</issn><publisher><publisher-name>RPA</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3031-2021-22-1-50-57</article-id><article-id custom-type="elpub" pub-id-type="custom">detstom-455</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLE</subject></subj-group></article-categories><title-group><article-title>Изменение микробиоты ротовой полости и ее коррекция у детей 6-12 лет, находящихся на ортодонтическом лечении съемными аппаратами</article-title><trans-title-group xml:lang="en"><trans-title>Changes in the oral microbiota and its correction in 6- to 12-year-old children undergoing orthodontic treatment with removable appliances</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4866-0548</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Разилова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Razilova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Разилова Алина Владимировна - аспирант кафедры детской, профилактической стоматологии и ортодонтии Института стоматологии им. Е.В. Боровского.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Alina V. Razilova - DMD, PhD student, Department of the Pediatric, Preventive Dentistry and Orthodontics, E.V. Borovsky Institute of Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University).</p><p>Moscow.</p></bio><email xlink:type="simple">alina.razilova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7257-0991</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамедов</surname><given-names>Ад. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamedov</surname><given-names>Ad. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мамедов Адиль Аскерович - заслуженный врач РФ, доктор медицинских наук, профессор, кафедры детской, профилактической стоматологии и ортодонтии Института стоматологии им. Е.В. Боровского.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Adil A. Mamedov - Distinguished physician of the Russian Federation, DMD, PhD, DSc, Professor, Professor Department of Pediatric, Preventive Dentistry and Orthodontics, E.V. Borovsky Institute of Dentistry, I.M. Sechenov First Moscow State Medical University (Sechenov University).</p><p>Moscow.</p></bio><email xlink:type="simple">mmachildstom@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9289-4010</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Симонова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Simonova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Симонова Альбина Валерьевна - доктор медицинских наук, профессор, профессор кафедры общей врачебной практики.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Albina V. Simonova - MD, PhD, DSc, Professor, Department of General Medical Practice, M.F. Vladimirsky Moscow Regional Research and Clinical Institute (MONIKI).</p><p>Moscow.</p></bio><email xlink:type="simple">medlabnews@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский областной научно-исследовательский институт им. М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>M.F. Vladimirsky Moscow Regional Research Clinical Institute</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>05</day><month>04</month><year>2022</year></pub-date><volume>22</volume><issue>1</issue><fpage>50</fpage><lpage>57</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Разилова А.В., Мамедов А.А., Симонова А.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Разилова А.В., Мамедов А.А., Симонова А.В.</copyright-holder><copyright-holder xml:lang="en">Razilova A.V., Mamedov A.A., Simonova A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.detstom.ru/jour/article/view/455">https://www.detstom.ru/jour/article/view/455</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Установка съемных ортодонтических аппаратов в полости рта создает благоприятные условия для размножения многих микроорганизмов. Цель исследования - изучение и коррекция изменений микробиоты ротовой полости у детей 6-12 лет, находящихся на ортодонтическом лечении съемными аппаратами.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведено обследование и лечение съемными ортодонтическими аппаратами 62 пациентов 6-12 лет. Комплексная оценка гигиены полости рта проводилась до лечения и в динамике через 4 и 12 недель. Микробиологическое исследование ротовой полости определялось методом газовой хроматографии-масс-спектрометрии по Г.А. Осипову. Дети были рандомизированы на две группы путем случайной выборки - основную (n = 30) и группу сравнения (n = 32). Для коррекции миробиоценоза ротовой полости основной группе были назначены полоскание рта антисептиком 0,01% раствора бензилдиметил-миристоиламино-пропиламмония и лекарственное средство, содержащее штамм Bifidobacterium bifidum, выбор этого препарата был обусловлен тем, что является постоянным представителем микрофлоры человека, в норме находится во всех биотопах организма, в том числе и в ротовой полости.</p></sec><sec><title>Результаты</title><p>Результаты. Через 4 недели в группе сравнения достоверно уменьшилось количество детей с хорошим и удовлетворительным уровнем гигиены, а с неудовлетворительным и плохим уровнем гигиены - увеличилось. Через 12 недель отмечались достоверные различия значений индексов гигиены между основной и группой сравнения. В ротовой полости к 4-й неделе в обеих группах было выявлено увеличение уровня эндотоксина до 9,9 раз по сравнению с нормой, суммарного содержания микробных маркеров, увеличение количества S. aureus в 7,6 раза, грибов рода Candida - в 7,2 раза, Lactobacillus spp. - в 2,6 раза. Обнаружен дефицит постоянного представителя микрофлоры Bifidobacterium в 3,9 раза. На фоне приема Bifidobacterium bifidum в основной группе наблюдалась восстановление баланса бифидобактерий.</p></sec><sec><title>Заключение</title><p>Заключение. Съемные ортодонтические аппараты ухудшают микрофлору ротовой полости. Применение антисептика 0,01% раствора бензилдиметил-миристоиламино-пропиламмония для полоскания ротовой полости и препарата Bifidobacterium bifidum позволяет улучшить микробиоценоз ротовой полости.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. The removable orthodontic appliances create favourable conditions in the oral cavity for the multiplication of many microorganisms. Purpose. The study aimed to investigate and correct the changes in the oral microbiota of children aged 6-12 years old undergoing orthodontic treatment with removable appliances.</p></sec><sec><title>Material and methods</title><p>Material and methods. Sixty-two patients aged 6-12 were examined and treated with removable orthodontic appliances. We comprehensively assessed the oral hygiene at the baseline and followed up after 4 and 12 weeks of treatment. The microbiological evaluation of the oral cavity was performed by gas chromatography - mass spectrometry, according to G.A. Osipov. The children randomly formed two groups: the main group (n = 30) and the comparison group (n = 32). To correct the oral microbiocenosis, in the main group, a mouthwash with an antiseptic 0.01% benzyldimethyl-myristoylamino-propylammonium solution and a supplement containing a strain of Bifidobacterium bifidum, which is a permanent representative of the human microflora, were prescribed.</p></sec><sec><title>Results</title><p>Results. Four weeks later, the number of children with good and moderate oral hygiene levels significantly decreased in the comparison group, and the number of those with unsatisfactory and poor oral hygiene levels increased. After twelve weeks, there were significant differences in the oral hygiene index values between the main and comparison groups. By the fourth week, endotoxins increased up to 9.9 in the oral cavity in both groups compared with the normal of both groups compared with the normal, the total content of microbial markers rose, the number of S. aureus increased by a factor of 7.6; Candida spp. - by a factor of 7.2; Lactobacillus spp. - 2.6. The deficiency of Bifidobacterium, a permanent representative of the microflora, was 3.9 times. In the main group, the restoration of bifidobacteria balance was associated with Bifidobacterium bifidum intake.</p></sec><sec><title>Conclusion</title><p>Conclusion. Removable orthodontic appliances worsen the oral microflora. Rinse with an antiseptic 0.01% benzyldimethyl-myristoylamino-propylammonium solution and Bifidobacterium bifidum intake allowed improving the oral microbiocenosis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ортодонтическое лечение</kwd><kwd>съемные аппараты</kwd><kwd>дети 6-12 лет</kwd><kwd>микробиота полости рта</kwd></kwd-group><kwd-group xml:lang="en"><kwd>orthodontic treatment</kwd><kwd>removable appliances</kwd><kwd>6-12-year-old children</kwd><kwd>oral microbiota</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мамедов Ад.А, Геппе Н, редакторы. Стоматология детского возраста. Учебное пособие. Mockea: ГЭ-ОТАР-Медиа. 2020:184 с. doi: 10.33029/9704-5275-2-SDV-2020-1-184</mixed-citation><mixed-citation xml:lang="en">Mamedov AdA, Geppe N, editor. Dentistry of childhood. Textbook. 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