detstomСтоматология детского возраста и профилактикаPediatric dentistry and dental prophylaxis1683-30311726-7218RPA10.33925/1683-3031-2021-21-2-95-102detstom-358Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLEОртодонтическое лечение с применением элайнеров и реминерализация эмали у подростковOrthodontic treatment with clear aligners and enamel remineralization in adolescentshttps://orcid.org/0000-0002-8661-469XСайпееваМ. М.SaypeevaM. M.

Сайпеева Мария Михайловна, кандидат медицинских наук, доцент кафедры стоматологии детского возраста и ортодонтии

Екатеринбург

Maria M. Saipeeva, DMD, PhD, Associate Professor, Department of Pediatric Dentistry and Orthodontics

Yekaterinburg

marybel@bk.ruhttps://orcid.org/0000-0002-5089-0828БрусницынаЕ. В.BrusnitsynaE. V.

Брусницына Елена Викторовна, кандидат медицинских наук, доцент кафедры стоматологии детского возраста и ортодонтии

Екатеринбург

Elena V. Brusnitsyna, DMD, PhD, Associate Professor, Department of Pediatric Dentistry and Orthodontics

Yekaterinburg

lb1@mail.ruhttps://orcid.org/0000-0003-4122-2518БимбасЕ. С.BimbasE. S.

Бимбас Евгения Сергеевна, доктор медицинских наук, профессор, заведующая кафедрой стоматологии детского возраста и ортодонтии

Екатеринбург

Evgeniya S. Bimbas, Dr. Sci. (Med.), Professor, Department of Pediatric Dentistry and Orthodontics

Yekaterinburg

bimbases@gmail.comhttps://orcid.org/0000-0003-0806-1177ГавриловИ. В.GavrilovI. V.

Гаврилов Илья Валерьевич, кандидат медицинских наук, доцент кафедры биохимии

Екатеринбург

Ilia V. Gavrilov, PhD, DMD, PhD, Associate Professor, Department of biochemistry

Yekaterinburg

iliagavrilov18@yandex.ruhttps://orcid.org/0000-0002-3591-0608ЗакировТ. В.ZakirovT. V.

Закиров Тарас Валерьевич, кандидат медицинских наук, доцент кафедры стоматологии детского возраста и ортодонтии

Екатеринбург

Taras V. Zakirov, DMD, PhD, Associate Professor, Department of Pediatric Dentistry and Orthodontics

Yekaterinburg

sekir-zakirov@mail.ruhttps://orcid.org/0000-0002-6920-519XТрубинаВ. А.TrubinaV. A.

Трубина Валерия Александровна, студентка 5 курса стоматологического факультета

Екатеринбург

Valeriya А. Trubina, fifth-year dental student

Yekaterinburg

lerat_01@mail.ruУральский государственный медицинский университетРоссияUral State Medical UniversityRussian Federation20211707202121295102Copyright © Сайпеева М.М., Брусницына Е.В., Бимбас Е.С., Гаврилов И.В., Закиров Т.В., Трубина В.А., 20212021Сайпеева М.М., Брусницына Е.В., Бимбас Е.С., Гаврилов И.В., Закиров Т.В., Трубина В.А.Saypeeva M.M., Brusnitsyna E.V., Bimbas E.S., Gavrilov I.V., Zakirov T.V., Trubina V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.detstom.ru/jour/article/view/358

Актуальность. Проведена оценка эффективности нового реминерализующего препарата PRESIDENT®PROFI REM "MINERALS GEL" на этапах ортодонтического лечения с применением элайнеров у подростков с пониженной резистентностью эмали.Материалы и методы. Проведено открытое одноцентровое несравнительное исследование применения PRESIDENT®PROFI REM "MINERALS GEL", в котором приняли участие 20 добровольцев, длительность исследования 1 месяц. Средний возраст пациентов составил 14,9 ± 1,1 год.Результаты. Во время ортодонтического лечения с помощью элайнеров и одномоментного использования реминерализующего геля через месяц исследования выявлено снижение ИГР-У на 24,75%, PMA на 44,33%, ТЭР на 17,11%. В биохимических показателях смешанной слюны выявлено повышение рН с 6,97 ± 0,16 до 7,69 ± 0,11, кальция – на 48,5%, снижение антиоксидантной активности – на 29,36%. Качество жизни подростков в период ортодонтического лечения снижается по опроснику OHIP-14 за счет проблем в общении, выявленных у 75% пациентов с элайнерами. Качество жизни при лечении на элайнерах с одновременной реминерализующей терапией достоверно выше, чем при традиционном лечении на НОТ (4,25 ± 0,86 баллов в группе применения элайнеров и 7,05 ± 1,16 баллов в группе брекетов).Выводы. Реминерализующий препарат PRESIDENT®PROFI REM "MINERALS GEL" обладает противоналет ным и минерализующим действием. Качество жизни при лечении с помощью элайнеров с одновременной реминерализующей терапией достоверно выше, чем при традиционном лечении на НОТ.

Relevance. The effectiveness of the new remineralizing agent PRESIDENT®PROFI REM "MINERALS GEL" was assessed at different stages of clear aligner orthodontic treatment in adolescents with reduced enamel resistance.Materials and methods. PRESIDENT®PROFI REM "MINERALS GEL" was evaluated in a one-month open, single center, non-comparative study where 20 adolescents took part (mean age 14.9 ± 1.1 years).Results. OHI-S decreased by 24.75%, PMA and ERT reduced by 44.33% and 17.11% respectively, after one month of the orthodontic treatment with clear aligners and simultaneous use of the remineralizing gel. The pH in the mixed saliva increased from 6.97 ± 0.16 to 7.69 ± 0.11, calcium went up by 48.5%, and the total antioxidant activity decreased by 29.36% (according to the mixed saliva biochemical parameters). The OHIP-14 questionnaire revealed that the quality of life decreased in 75% of adolescent patients during the orthodontic treatment with aligners due to "communication problems". The quality of life was significantly higher during the aligner treatment with simultaneous remineralizing therapy than during the conventional treatment with fixed appliances (4.25 ± 0.86 points in the aligner group versus 7.05 ± 1.16 points – the brackets group).Conclusions. The remineralizing gel PRESIDENT®PROFI REM "MINERALS GEL" has an anti-plaque and mineralizing effect. The quality of life is significantly higher during the clear aligner treatment with simultaneous remineralizing therapy than during the conventional treatment with fixed appliances.

элайнерыподросткиминерализация эмалиNovaМinксилитclear alignersadolescentsenamel minerlizationNovaminxylitolReferencesШакирова РР, Мосеева МВ, Мельчукова ЗА, Урсегов АА. Совершенствование системы обеспечения стоматологического здоровья подростков. Стоматология детского возраста и профилактика. 2020;20(1):27-31. https://doi.org/10.33925/1683-3031-2020-20-1-27-31.Shakirova RR, Moiseeva MV, Melchukova ZA, Ursegov AA. The improvement of the providing system of dental health of teenagers. Paediatric dentistry and prophylaxis. 2020;20(1):27-31. (In Russ.). https://doi.org/10.33925/1683-3031-2020-20-1-27-31.Брусницына ЕВ, Закиров ТВ, Сайпеева ММ, Иощенко ЕС, Шешенина СА. Гиперчувствительность зубов после ортодонтического лечения в подростковом возрасте. Стоматология детского возраста и профилактика. 2020;20(3):217-222. https://doi.org/10.33925/1683-3031-2020-20-3-217-222.Brusnitsyna EV, Zakirov TV, Saipeeva MM, Ioshchenko ES, Sheshenina SA. Hypersensitivity of teeth after orthodontic treatment in adolescence. Paediatric dentistry and prophylaxis. 2020;20(3):217-222. (In Russ.). https://doi.org/10.33925/1683-3031-2020-20-3-217-222.Шуминская ТА. Прогнозирование риска поражения зубов у детей при лечении несъемной ортодонтической аппаратурой. The Unity Of Science: International Scientific Periodical Journal. 2015;3:184-186. Режим доступа: https://elibrary.ru/item.asp?id=25299919.Shuminskaya Т. Predicting the risk of dental disases in children treated with a fixed orthodontic equipment. The Unity Of Science: International Scientific Periodical Journal. 2015;3:184-186 (In Russ.). Available from: https://elibrary.ru/item.asp?id=25299919.Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A. Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: A meta-analysis. Journal of International Society of Preventive and Community Dentistry. 2015;NovDec;5(6):433-9. https://doi:10.4103/2231-0762.167719.Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A. Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: A meta-analysis. Journal of International Society of Preventive and Community Dentistry. 2015;Nov-Dec;5(6):433-9. https://doi:10.4103/2231-0762.167719.Khoroushi M, Kachuie M. Prevention and Treatment of White Spot Lesions in Orthodontic Patients. Contemporary Clinical Dentistry. 2017;8(1):11-19. https://doi:10.4103/ccd.ccd_216_17.Khoroushi M, Kachuie M. Prevention and Treatment of White Spot Lesions in Orthodontic Patients. Contemporary Clinical Dentistry. 2017;8(1):11-19. https://doi:10.4103/ccd.ccd_216_17.Lopatiene K, Borisovaite M, Lapenaite E. Prevention and Treatment of White Spot Lesions During and After Treatment with Fixed Orthodontic Appliances: a Systematic Literature Review. Journal of Oral & Maxillofacial Research. 2016;30;7(2): e1. https://doi:10.5037/jomr.2016.7201.Lopatiene K, Borisovaite M, Lapenaite E. Prevention and Treatment of White Spot Lesions During and After Treatment with Fixed Orthodontic Appliances: a Systematic Literature Review. Journal of Oral & Maxillofacial Research. 2016;30;7(2): e1. https://doi:10.5037/jomr.2016.7201.Azeem M, Ul Hamid W. Incidence of White Spot lesions during Clear Aligner Theraphy. Journal of World Federation of Orthodontists. 2017;6:127-130. https://doi:10.5037/jomr.2016.7201.Azeem M, Ul Hamid W. Incidence of White Spot lesions during Clear Aligner Theraphy. Journal of World Federation of Orthodontists. 2017;6:127-130. https://doi:10.5037/jomr.2016.7201.Buschang PH, Chastain D, Keylor CL, Crosby D, Julien KC. Incidence of white spot lesions among patients treated with clear aligners and traditional braces. The Angle Orthodontist. 2019;May;89(3):359-364. https://doi:10.2319/073118-553.1.Buschang PH, Chastain D, Keylor CL, Crosby D, Julien KC. Incidence of white spot lesions among patients treated with clear aligners and traditional braces. The Angle Orthodontist. 2019;May;89(3):359-364. https://doi:10.2319/073118-553.1.Al-Seraidi M, Hansa I, Dhaval F, Ferguson DJ, Vaid NR. The effect of vestibular, lingual, and aligner appliances on the quality of life of adult patients during the initial stages of orthodontic treatment. Progress in Orthodontics. 2021;Jan;18;22(1):3. https://doi:10.1186/s40510-020-00346-0.Al-Seraidi M, Hansa I, Dhaval F, Ferguson DJ, Vaid NR. The effect of vestibular, lingual, and aligner appliances on the quality of life of adult patients during the initial stages of orthodontic treatment. Progress in Orthodontics. 2021;Jan;18;22(1):3. https://doi:10.1186/s40510-020-00346-0.Paes da Silva S, Pitchika V, Baumert U, Wehrbein H, Schwestka-Polly R, Drescher D, Kühnisch J, Wichelhaus A. Oral health-related quality of life in orthodontics: a crosssectional multicentre study on patients in orthodontic treatment. European Journal of Orthodontics. 2020;42,Issue 3:270-280. https://doi.org/10.1093/ejo/cjz064.Paes da Silva S, Pitchika V, Baumert U, Wehrbein H, Schwestka-Polly R, Drescher D, Kühnisch J, Wichelhaus A. Oral health-related quality of life in orthodontics: a cross-sectional multicentre study on patients in orthodontic treatment. European Journal of Orthodontics. 2020;42,Issue 3:270-280. https://doi.org/10.1093/ejo/cjz064.White DW, Julien KC, Jacob H, Campbell PM, Buschang PH. Discomfort associated with Invisalign and traditional brackets: A randomized, prospective trial. The Angle Orthodontist. 2017;Nov;87(6):801-808. https://doi:10.2319/091416-687.1.White DW, Julien KC, Jacob H, Campbell PM, Buschang PH. Discomfort associated with Invisalign and traditional brackets: A randomized, prospective trial. The Angle Orthodontist. 2017;Nov;87(6):801-808. https://doi:10.2319/091416-687.1.Ma X, Lin X, Zhong T, Fangfang Х. Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: a systematic review and metaanalysis. BMC Oral Health. 2019;19:295. https://doi.org/10.1186/s12903-019-0977-0.Ma X, Lin X, Zhong T. Fangfang Х. Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: a systematic review and metaanalysis. BMC Oral Health. 2019;19:295. https://doi.org/10.1186/s12903-019-0977-0.Ballard RW, Hagan JL, Phaup AN, Sarkar N, Townsend JA, Armbruster PC. Evaluation of 3 commercially available materials for resolution of white spot lesions. American Journal of Orthodontics and Dentofacial Orthopedics. 2013;143(4):78-84. https://doi:10.1016/j.ajodo.2012.08.020.Ballard RW, Hagan JL, Phaup AN, Sarkar N, Townsend JA, Armbruster PC. Evaluation of 3 commercially available materials for resolution of white spot lesions. American Journal of Orthodontics and Dentofacial Orthopedics. 2013;143(4):78-84. https://doi:10.1016/j.ajodo.2012.08.020.Earl JS, Leary RK, Muller K, Langford RM, Greenspan DC. Physical and chemical characterization of dentin surface following treatment with Novamin technology. Journal of Investigative and Clinical Dentistry. 2011;22(Spec Iss):62-67.Available from: https://europepmc.org/article/med/21905399.Earl JS, Leary RK, Muller K, Langford RM, Greenspan DC. Physical and chemical characterization of dentin surface following treatment with Novamin technology. Journal of Investigative and Clinical Dentistry. 2011;22(Spec Iss):62-67. Available from: https://europepmc.org/article/med/21905399.Khijmatgar S, Reddy U, John S, Badavannavar AN, Souza TD. Is there evidence for Novamin application in remineralization? A Systematic review. Journal of Oral Biology and Craniofacial Research. 2020;10(2):87-92. https://doi:10.1016/j.jobcr.2020.01.001.Khijmatgar S, Reddy U, John S, Badavannavar AN, Souza TD. Is there evidence for Novamin application in remineralization? A Systematic review. Journal of Oral Biology and Craniofacial Research. 2020;10(2):87-92. https://doi:10.1016/j.jobcr.2020.01.001.Manoharan V, Kumar RK, Sivanraj AK, Arumugam SB. Comparative Evaluation of Remineralization Potential of Casein Phosphopeptide-Amorphous Calcium Fluoride Phosphate and Novamin on Artificially Demineralized Human Enamel: An In vitro Study.Contemporary Clinical Dentistry. 2018;9(Suppl 1):S58-S63. https://doi:10.4103/ccd.ccd_28_18.Manoharan V, Kumar RK, Sivanraj AK, Arumugam SB. Comparative Evaluation of Remineralization Potential of Casein Phosphopeptide-Amorphous Calcium Fluoride Phosphate and Novamin on Artificially Demineralized Human Enamel: An In vitro Study.Contemporary Clinical Dentistry. 2018;9(Suppl 1):S58-S63. https://doi:10.4103/ccd.ccd_28_18.Rajendran R, Kunjusankaran RN, Sandhya R, Anilkumar A, Santhosh R. Comparative Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study Pesqui. Brazilian research in Pediatric Dentistry and Integrated Clinic. 2019;19:e4668. http://doi.org/10.4034/PBOCI.2019.191.61.Rajendran R, Kunjusankaran RN, Sandhya R, Anilkumar A, Santhosh R. Comparative Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study Pesqui. Brazilian research in Pediatric Dentistry and Integrated Clinic. 2019;19:e4668. http://doi.org/10.4034/PBOCI.2019.191.61.Suryani H, Gehlot PM, Manjunath MK. Evaluation of the remineralisation potential of bioactive glass, nanohydroxyapatite and casein phosphopeptide-amorphous calcium phosphate fluoride-based toothpastes on enamel erosion lesion – An Ex Vivo study. Indian Journal of Dental Research. 2020; 31:670-677. Available from: https://www.ijdr.in/text.asp?2020/31/5/670/306459.Suryani H, Gehlot PM, Manjunath MK. Evaluation of the remineralisation potential of bioactive glass, nanohydroxyapatite and casein phosphopeptide-amorphous calcium phosphate fluoride-based toothpastes on enamel erosion lesion – An Ex Vivo study. Indian Journal of Dental Research. 2020; 31:670-677. Available from: https://www.ijdr.in/text.asp?2020/31/5/670/306459.Афиногенов ГЕ, Афиногенова АГ, Доровская ЕН, Матело СК. Влияние ксилита в составе зубных паст на специфическую адгезию некоторых клинических штаммов микроорганизмов полости рта. Стоматология детского возраста и профилактика. 2008;2(25):73-78. Режим доступа: https://www.elibrary.ru/item.asp?id=11644858.Afinogenov GE, Afinogenov AG, Dorovskaya EN, Matelo SK. The effect of xylitol in toothpastes on specific adhesion of some clinical strains of oral microorganisms. Paediatric dentistry and prophylaxis. 2008; 2(25):73-78. (In Russ.). Available from: https://www.elibrary.ru/item.asp?id=11644858.Janakiram C, Deepan Kumar CV, Joseph J. Xylitol in preventing dental caries: A systematic review and metaanalyses. Journal of Natural Science, Biology and Medicine. 2017;8(1):16-21. http://doi:10.4103/0976-9668.198344.Janakiram C, Deepan Kumar CV, Joseph J. Xylitol in preventing dental caries: A systematic review and metaanalyses. Journal of Natural Science, Biology and Medicine. 2017;8(1):16-21. http://doi:10.4103/0976-9668.198344.Бельская ЛВ, Сарф ЕА, Косенок ВК, Массард Ж. Антиоксидантная активность смешанной слюны человека в норме. Экология человека. 2017;6:36-40. Режим доступа: https://cyberleninka.ru/article/n/antioksidantnaya-aktivnost-smeshannoy-slyuny-cheloveka-v-norme.Bel’skaya LV, Sarf EA, Kosenok VK, Massard Zh. Antioxidant Activity of Human Mixed Saliva in Norm. Human Ecology. 2017;6:36-40 (In Russ.). Available from: https://cyberleninka.ru/article/n/antioksidantnaya-aktivnost-smeshannoy-slyuny-cheloveka-v-norme.

The authors declare that there are no conflicts of interest present.