detstomСтоматология детского возраста и профилактикаPediatric dentistry and dental prophylaxis1683-30311726-7218RPA10.33925/1683-3031-2020-20-4-304-309detstom-310Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLEУровень иммуноглобулина А в слюне в зависимости от наличия и тяжести раннего детского кариесаThe level of immunoglobulin A in saliva depending on the presence and severity of early childhood carieshttps://orcid.org/0000-0002-1519-0172ОсокинаА. С.OsokinaA. S.

Осокина Анастасия Сергеевна - кандидат медицинских наук, доцент кафедры стоматологии детского возраста.

Волгоград

Osokina Anastasia S. - PHD, Associate Professor of Paediatric Dentistry Department.

Volgograd

osoka_as@mail.ruhttps://orcid.org/0000-0003-2011-9714МаслакЕ. Е.MaslakE. E.

Маслак Елена Ефимовна - доктор медицинских наук, профессор кафедры стоматологии детского возраста.

Волгоград

Maslak Elena E. - PhD, MD, DSc, Professor of Pediatric Dentistry Department.

Volgograd

eemaslak@yandex.ruhttps://orcid.org/0000-0003-2974-1497ЯковлевА. Т.YakovlevA. T.

Яковлев Анатолий Трофимович - доктор медицинских наук, профессор, заведующий кафедрой клинической лабораторной диагностики.

Волгоград

Yakovlev Anatoliy T. - PhD, MD, DSc, Professor, Head of Clinical Laboratory Diagnostics Department.

Volgograd

atyakovlev@volgmed.ruВолгоградский государственный медицинский университетРоссияVolgograd State Medical UniversityRussian Federation202026012021204304309Copyright © Осокина А.С., Маслак Е.Е., Яковлев А.Т., 20212021Осокина А.С., Маслак Е.Е., Яковлев А.Т.Osokina A.S., Maslak E.E., Yakovlev A.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.detstom.ru/jour/article/view/310Актуальность

Актуальность. Иммунологическая зашита играет существенную роль в развитии раннего детского кариеса (early childhood caries, ECC).

Цель исследования - изучить уровень секреторного иммуноглобулина A (SIgA) в слюне детей в зависимости от наличия и тяжести раннего детского кариеса.

Материалы и методы

Материалы и методы. В исследовании участвовали 225 детей: 60 в возрасте 1-2 лет (1-я группа) и 165 -3-5 лет (2-я группа). В 1-й группе сформированы две подгруппы (по 30 детей): без кариеса (CF-1) и с тяжелой формой ECC (S-ECC-1). Во 2-й группе сформированы три подгруппы (по 55 детей): без кариеса (CF-2), с ECC (ECC-2) и тяжелой формой ECC (S-ECC-2). SIgA в слюне (г/л) определяли с помощью набора IgA SALIVA ELISA. Для статистического анализа использовали программу Statistica 6.

Результаты

Результаты. Уровни SIgA в слюне детей в подгруппах CF-1 и S-ECC-1 составляли 37,40 ± 1,77 и 10,00 ± 0,67 (р < 0,001), в подгруппах CF-2, ECC-2 и S-ECC-2, соответственно, 36,77 ± 2,58, 20,67 ± 1,08 и 9,83 ± 0,38 (р < 0,001). В 1-й и 2-й группах выявлена значимая сильная обратная корреляция Пирсона (г = -0,7-0,8) между уровнями SIgA в слюне и наличием у детей тяжелой формы ECC.

Выводы

Выводы. Уровень SIgA в слюне отражает восприимчивость детей к кариесу. Выявлена сильная существенная обратная корреляционная зависимость между уровнем SIgA и наличием S-ECC у детей.

Relevance

Relevance. Immune defense plays a significant role in early childhood caries (ECC) development in children. The aim of the research was to study the level of secretory immunoglobulin A (SIgA) in the saliva of the children depending on the presence and severity of early childhood caries.

Materials and methods

Materials and methods. 225 children participated in the study: 60 1-2-year-olds (the 1st group) and 165 3-5-year-olds (the 2nd group). In the 1st group 2 subgroups (30 children each) were formed: caries free (CF-1) and with severe ECC (S-ECC-1). In the 2nd group 3 subgroups (55 children each) were formed: caries free (CF-2), with ECC (ECC-2) and severe ECC (S-ECC-2). SIgA in the saliva (g/l) was measured by «IgA SALIVA ELISA» kit. The program Statistica 6 was used for statistical analysis.

Results

Results. SIgA levels in the saliva were 37.40 ± 1.77 and 10.00 ± 0.67 in the subgroups CF-1 and S-ECC-1 (p < 0.001), 36.77 ± 2.58, 20.67 ± 1.08 and 9.83 ± 0.38 in the subgroups CF-2, ECC-2 и S-ECC-2 respectively (p < 0.001). In the first and second groups significant strong inverse Pierson correlation (r = -0.7-0.8) was revealed between SIgA levels in the saliva and S-ECC presence in the children.

Conclusions

Conclusions. The level of SIgA in the saliva reflects children's susceptibility to caries. Significant strong inverse correlation was revealed between SIgA in the saliva and severe ECC in the children.

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The authors declare that there are no conflicts of interest present.