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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">detstom</journal-id><journal-title-group><journal-title xml:lang="ru">Стоматология детского возраста и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Pediatric dentistry and dental prophylaxis</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3031</issn><issn pub-type="epub">1726-7218</issn><publisher><publisher-name>RPA</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3031-2020-20-3-244-250</article-id><article-id custom-type="elpub" pub-id-type="custom">detstom-250</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Опухоли орофациальной зоны у детей и подростков (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Tumors of the orofacial zone in children and adolescents (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6899-7105</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жуковская</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhukovskaya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующая отделом изучения поздних эффектов противоопухолевой терапии </p><p>Москва</p></bio><bio xml:lang="en"><p>PhD, MD, DSс, Professor, Head of the Department for the Study of the Late Effects of Antitumor Therapy,  «Russkoe Pole» medical and rehabilitation research center </p><p>Moscow</p></bio><email xlink:type="simple">elena_zhukovskay@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3606-8491</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Обухов</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Obukhov</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-стоматолог, м.н.с. отдела изучения поздних эффектов противоопухолевой терапии </p><p>Москва</p></bio><bio xml:lang="en"><p>dentist, junior researcher of the department for the study of late effects of anticancer therapy, «Russkoe Pole» medical and rehabilitation research center</p><p>Moscow</p></bio><email xlink:type="simple">l5016547@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0533-9233</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карелин</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Karelin</surname><given-names>A. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., главный врач </p><p>Москва</p></bio><bio xml:lang="en"><p>PhD, Chief Physician, «Russkoe Pole» medical and rehabilitation research center</p><p>Moscow</p></bio><email xlink:type="simple">alexandr.karelin@fccho-moscow.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Лечебно-реабилитационный научный центр «Русское поле» «НМИЦ ДГОИ им. Дмитрия Рогачева»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal state budgetary institution Dmitry Rogachev national medical research center for pediatric Hematology, Oncology and immunology of the Ministry of health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>09</day><month>10</month><year>2020</year></pub-date><volume>20</volume><issue>3</issue><fpage>244</fpage><lpage>250</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жуковская Е.В., Обухов Ю.А., Карелин А.Ф., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Жуковская Е.В., Обухов Ю.А., Карелин А.Ф.</copyright-holder><copyright-holder xml:lang="en">Zhukovskaya E.V., Obukhov Y.A., Karelin A.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.detstom.ru/jour/article/view/250">https://www.detstom.ru/jour/article/view/250</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Актуальность представленного авторами обзора литературы обусловлена многообразием и сложностью дифференциального диагноза опухолей орофациальной зоны у детей и подростков. На фоне абсолютного преобладания доброкачественных новообразований около 10-20% приходится на долю злокачественных новообразований  этой области. В связи с этим часто специалисты поликлиник не проявляют достаточной  онкологической настороженности, что приводит к неоправданному удлинению  диагностического периода и поздней диагностике злокачественных новообразований.</p><p>Целью обзора литературы является обсуждение результатов исследований, посвященных эпидемиологическим, клиническим и терапевтическим особенностям опухолевого процесса в орофациальной зоне у детей и подростков.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Поиск публикаций по тематике обзора выполнен в базах: https://www.ncbi.nlm.nih.gov/, https://elibrary.ru/cit_title_items.asp, https://www.researchgate.net/, https://elibrary.ru/. Авторы описывают клинические  проявления опухолей в зависимости от локализации поражения и гистологической  принадлежности. Инициальные симптомы как злокачественных, так и  доброкачественных новообразований часто неспецифичны. Преобладающие доброкачественные новообразования могут быть излечены исключительно хирургическим путем. Значительно реже у детей и подростков  встречаются и злокачественные новообразования: плоскоклеточный рак ротовой  полости, лангергансклеточный гистиоцитоз и другие, которые лечатся в соответствии с принципами комплексной / комбинированной противоопухолевой терапии, включая проведение курсов минимизировать объем реабилитации.</p></sec><sec><title>Результаты</title><p>Результаты. Своевременная диагностика и профилактика развития новообразований  орофациальной области позволяют снизить тяжесть морфофункциональных нарушений у  детей и подростков. Несмотря на применение эффективных методик хирургической  или комбинированной терапии многие нуждаются в проведении реабилитационных  мероприятий.</p></sec><sec><title>Выводы</title><p>Выводы. Оптимальной позицией врача-педиатра, терапевта, стоматолога, хирурга на  этапе диагностики опухоли должна быть реализация онкологической настороженности,  предполагающей активный подход без длительного динамического наблюдения пациентов. Онкологическая настороженность, в первую очередь врачей-стоматологов, позволит улучшить результаты противоопухолевой терапии у пациентов с опухолями орофациальной локализацией. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. The relevance of the literature review presented by the authors is due to the diversity and complexity of the differential diagnosis of tumors of the orofacial zone in children and adolescents. Against the background of the absolute predominance of benign neoplasms, about 10-20% falls on the share of malignant neoplasms in this area. In this regard, polyclinic specialists often do not show sufficient oncological alertness, which leads to an unjustified lengthening of the diagnostic period and late diagnosis of malignant neoplasms.</p><p>The purpose of the literature review is to discuss the results of studies on the epidemiological, clinical and therapeutic features of the tumor process in the orofacial zone in children and adolescents.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The searching of publications on the subject of the review were performed in the databases: https://www.ncbi.nlm.nih.gov/, https://elibrary.ru/cit_title_items.asp, https://www.researchgate.net/, https://elibrary.ru/. The authors describe the clinical manifestations of tumors depending on the location of the lesion and histological affiliation. The initial symptoms of both malignant and benign neoplasms are often nonspecific. Prevailing benign neoplasms can only be treated by surgery. Much less often in children and adolescents, malignant neoplasms are also found: squamous cell carcinoma of the oral cavity, Langerhans cell histiocytosis and others, which are treated in accordance with the principles of complex / combined anticancer therapy, including courses to minimize the amount of rehabilitation.</p></sec><sec><title> </title><p> </p></sec><sec><title>Results</title><p>Results. Timely diagnosis and prevention of the development of neoplasms in the orofacial area can reduce the severity of morphological and functional disorders in children and adolescents. Despite the use of effective methods of surgical or combination therapy, many need rehabilitation measures.</p></sec><sec><title>Conclusions</title><p>Conclusions. The optimal position of a pediatrician, therapist, dentist, or surgeon at the stage of tumor diagnosis should be the implementation of oncological alertness, which implies an active approach without long-term "dynamic observation" of patients. Oncological alertness, especially among dentists, will improve the results of antitumor therapy in patients with Orofacial tumors.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>опухоли</kwd><kwd>орофациальная зона</kwd><kwd>карцинома</kwd><kwd>дети и подростки</kwd><kwd>противоопухолевая терапия</kwd><kwd>профилактика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tumors</kwd><kwd>orofacial zone</kwd><kwd>carcinoma</kwd><kwd>children and adolescents</kwd><kwd>antitumor therapy</kwd><kwd>prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">G. J. Draper, J. F. Bithell, K. J. Bunch et al. Childhood cancer research in Oxford II: The Childhood Cancer Research Group.Br J Cancer. 2018;Sep;11;119(6):763-770. Published online 2018 Aug 21. https://doi.org/10.1038/s41416-018-0181-z.</mixed-citation><mixed-citation xml:lang="en">G. J. Draper, J. F. Bithell, K. J. 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