Актуальность

detstom

Стоматология детского возраста и профилактика

Pediatric dentistry and dental prophylaxis

1683-30311726-7218

RPA

10.33925/1683-3031-2020-20-1-70-76

detstom-204

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVIEW

Пародонтопатогены: новый взгляд. Систематический обзор. Часть 1

Periodontopathogens: a new view. Systematic review. Part 1

https://orcid.org/0000-0002-4527-7471

Слажнева

Е. С.

Slazhneva

E. S.

Слажнева Екатерина Сергеевна, очный аспирант кафедры пародонтологии

Москва

Slazhneva Ekaterina S., Post-graduate student of the Department of Periodontology

Moscow

katushkor@mail.ru

https://orcid.org/0000-0002-4439-9661

Тихомирова

Е. А.

Tikhomirova

E. A.

Тихомирова Екатерина Александровна, очный аспирант кафедры пародонтологии

Москва

Tihomirova Ekaterina A., Post-graduate student of the Department of Periodontology

Moscow

lukaly1990@mail.ru

https://orcid.org/0000-0002-4141-1370

Атрушкевич

В. Г.

Atrushkevich

V. G.

Атрушкевич Виктория Геннадьевна, д.м.н., профессор кафедры пародонтологии, вице-президент Российской пародонтологической ассоциации

Москва

Atrushkevich Victoria G., DSc, professor of the Department of Periodontology, ,Vice-President of RPA

Moscow

atrushkevichv@mail.ru

Московский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияMoscow State University of Medicine and Dentistry named after A.I. EvdokimovRussian Federation

2020

01042020

2017076

2020

Слажнева Е.С., Тихомирова Е.А., Атрушкевич В.Г.

Slazhneva E.S., Tikhomirova E.A., Atrushkevich V.G.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.detstom.ru/jour/article/view/204

Актуальность

Актуальность. Современный взгляд на пародонтит как на дисбиотическое заболевание, возникающее в результате изменения микробного состава поддесневой области, рассмотрено в систематическом обзоре.

Цель

Цель. Изучить новую парадигму развития генерализованного пародонтита. Материалы и методы. Для изучения отбирались рандомизированные контролируемые исследования (РКИ), в том числе кластерные РКИ, контролируемые (нерандомизированные) микробиологические и клинические исследования микробиома полости рта у взрослых пациентов с генерализованным пародонтитом за последние 10 лет.

Результаты

Результаты. Развитие дисбиоза пародонта происходит в течение некоторого периода времени, который медленно превращает симбиотическую ассоциацию хозяина и микроба в патогенную. В этом обзоре рассматривается современная парадигма прогрессирования пародонтита, которая ставит под сомнение традиционную концепцию заболевания, индуцируемого несколькими частными пародонтопатогенными микроорганизмами, принадлежащими к красному комплексу.

Выводы

Выводы. Как следует из современной литературы, пародонтит в определенной степени вызван переходом от гармоничного симбиотического бактериального сообщества к дисбиотическому. Последние научные исследования показали, что один микроорганизм не способен вызывать заболевание, что к развитию патологии приводит деятельность микробного сообщества в целом.

Relevance

Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review.

Purpose

Purpose. To study a new paradigm of development of generalized periodontitis.

Materials and methods

Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years.

Results

Results. The development of periodontal dysbiosis occurs over a period of time, which slowly turns the symbiotic association of the host and microbe into a pathogenic one. This review examines the current paradigm of periodontitis progression, which calls into question the traditional concept of a disease induced by several particular periodontal pathogens belonging to the red complex.

Conclusions

Conclusions. As follows from modern literature periodontitis is to a certain extent caused by the transition from a harmonious symbiotic bacterial community to a dysbiotic one. Recent scientific studies have shown that not single microorganism is not able to cause disease but the microbial community as a whole leads to the development of pathology.

дисбиозполимикробная синергиямикробная биопленкапародонтит

dysbiosispolymicrobial synergymicrobial biofilmperiodontitis

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The authors declare that there are no conflicts of interest present.